Sure, I practiced that with my husband for a while. He would dress up in sexy underwear of mine. A favorite outfit was a matching hot pink bra and panty set if mine and he would add white thigh hight stockings as well. He shaved pretty much all of his body hair off to make him more feminine. Then I would fuck him in the ass with a strapon that we had. I would make him say that he was the "girl." "Who's the girl?" "I am" he would reply. He is outwardly masculine and athletic, so no one would be suspicious.
It was a turn on for me to take the dominant masculine role. It was arousing for him, so that gave me some pleasure as well.