Hello Everybody, I have recently completed my bachelor’s degree in chemistry. From last few days I am suffering from heartburn after almost every meal. My doctor has prescribed me to take prevacid also known as lansoprazole. As a student of chemistry I eager to know what are the constituents of prevacid. I will appreciate any information regarding this. --------------------------------- Lopez
PREVACID The active ingredient in PREVACID capsules is a substituted benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl] benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C16H14F3N3O2S with a molecular weight of 369.37. The structural formula is: Lansoprazole is a white to brownish-white odorless crystalline powder which melts with decomposition at approximately 166°C. Lansoprazole is freely soluble in dimethylformamide; soluble in methanol; sparingly soluble in ethanol; slightly soluble in ethyl acetate, dichloromethane and acetonitrile; very slightly soluble in ether; and practically insoluble in hexane and water. Lansoprazole is stable when exposed to light for up to two months. The rate of degradation of the compound in aqueous solution increases with decreasing pH. The degradation half-life of the drug substance in aqueous solution at 25ºC is approximately 0.5 hour at pH 5.0 and approximately 18 hours at pH 7.0. PREVACID capsules contain enteric-coated granules consisting of lansoprazole (15 mg) [active ingredient], hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, colloidal silicon dioxide, magnesium carbonate, methacrylic acid copolymer, starch, talc, sugar sphere, sucrose, polyethylene glycol, polysorbate 80, and titanium dioxide [inactive ingredients]. Components of the gelatin capsule include gelatin, titanium dioxide, D&C Red No. 28, FD&C Blue No. 1, FD&C Green No. 3, and FD&C Red No. 40 [inactive ingredients].
Hi Lopez, Prevacid or lansoprazole is a very effective in treatment of heartburn and acid reflux disease. The active ingredient in lansoprazole is a white to brownish-white odorless crystalline powder which melts at approximately 166° C. The active ingredient in lansoprazole is substituted benzimidazole, a compound that inhibits gastric acid secretion. Molecular mass of this compound is 369.37. Lansoprazole is soluble in water and hexane. Lansoprazole is stable to light and is available in market as a capsule under brand name prevacid.
