you would have probably been a lot better off asking the psychadelics forum, as a lot of bozos on here will spit a bunch of BS at you. acid is relatively safe on the brain, the theory is it gets new neuropathways firing that wouldnt normally be firing, so you are actually using a little more of the tiny percent your brain normally uses, cuz yew cant even find the LSD in yer body like a couple hours after taking it, read more on erowid for info on myth clarification, and interesting stuff) no it doesnt stay in your spine, or brain, nor is it rat poison. but, here is the positive, negative, and neutral.. taken from http://www.erowid.org/chemicals/lsd/lsd.shtml (go there to read more)i bolded the ones i felt described it a little better, from My experience at least. POSITIVE increase in energy (stimulation) increase in associative & creative thinking mood lift increased awareness & appreciation of music increased awareness of senses. (eating, drinking, smell) closed and open eye visuals profound life-changing spiritual experiences NEUTRAL general change in consciousness (as with most psychoactives) pupil dilation difficulty focusing(???) increased salivation and mucus production (causes coughing in some people) unusual body sensations (facial flushing, chills, goosebumps, body energy) unusual thoughts and speech change in perception of time(what time?; ) quickly changing emotions (happiness, fear, gidiness, anxiety, anger, joy, irritation) slight increase in body temperature slight increase in heart rate NEGATIVE anxiety tension, jaw tension increased perspiration nausea dizziness, confusion megalomania over-awareness & over-sensitization to music and noise paranoia, fear, and panic unwanted and overwhelming feelings unwanted life-changing spiritual experiences flashbacks (negative? i don't mind 'em, and their no where near as intense as a real acid trip) wouldnt suggest more than 2 hits for your first time.