Alrighty, heres how the story goes. I had gotten some acid that my friend bought and dosed two times in one week. The day after the second acid usage, i had gotten some mushrooms that i sold him. The mushrooms were in chocolates and the guy who sold them to me claimed they were the same batch that i had gotten a week ago, that had proved to be very strong mushrooms. My friend ate those mushrooms and they did nothing for him, my other friend ate the mushrooms as well and they didnt do anything for him either. Both of them had taken acid the day before, one took 5 hits and the other took 2. So, were the mushrooms just shitty or is there a cross tolerance? did the mushies do basically nothing because they had taken acid recently? yeah...excuse my rough explanation. peace and love.
Yes there is a cross tolerance between LSD and Psilocybin and other active chemicals in shrooms. Best wait a couple days in between trips.
I don't like to waste doses or shrooms, so I always wait a couple of weeks between trips so its totally worth my while.
Based upon my experience, for me, approx two weeks OR more is needed for a strong effect. That is to say with the consumption of a normal dose. I really have no desire to take HUGE amounts to counter tolerance. It's a waste of money and seems a bit off. I've never tried taking more to do this though and in general the break between dosing to me is a nice thing, lets your brain rest from the intense thought/focus forced upon it.
physical tolerance is gone in 3 to 5 days. mind tolerance is longer, if you trip too often it loses its other-worldly quality.