I have a regimen including 5htp before I roll on e. I pyramid down all week until trip date 300mg-50mg. DO NOT TAKE IT ON AN EMPTY STOMACH...the most violent projectile vomitting episodes can occur. I space out the 300mg across the entire day when ever I eat a meal..day of the trip I prefer to have an empty stomach for at least 2 hours before kick off with NO 5htp taken during the roll. The next day a 50mg dose is taken in 2 25mg increments and this continues for 3 days. For me rolls never happen every second weekend at the most once every 3 weeks. Eat plenty of turkey and chicken to get natural tryptophan as well during the after roll....this helps especially if you are tolerant or overindulge haven't used the same with other chems except lucy and the regimen is much less intense one day before and one day after. Does this help?