NYC probably the biggest. My favorite city (so far) is Madrid, I kept getting so lost but the roads are set up to basically lead you back to the center, so it was awesome. Great food, beautiful people, fantastic night life, good times My least favorite city (again, so far) is Montreal. I probably dislike it because I didn't give it a fair chance though, I was drunk and soooo cold my whole time there, alls I wanted to do was get in bed and get warm. The city itself was really dirty, but again, this is from the perspective that I only spent time in dive bars and strip clubs hahaha.
hmm, well i guess the biggest as far as population is concerned would be nyc, but i have been to boston before, just like a LONG time ago. ive been to San Antonio and houston, st louis was cool, very clean in areas.
Minneapolis/St Paul, Chicago, St. Louis, Nashville, Kansas City Not sure which is the biggest, though.