never done opiates but i have some

Heres some reading just so this shite can be over with and the answers are NOT clear cut so personal experience is just that.Not taking sides just bring some studies to the table, I love a good debate and this is an interesting topic.

"There have not been extensive clinical studies of the analgesic potency of cannabinoids, but the available data from animal studies indicate that cannabinoids could be useful analgesics. In general, cannabinoids seem to be mild to moderate analgesics. Opiates, such as morphine and codeine, are the most widely used drugs for the treatment of acute pain, but they are not consistently effective in chronic pain; they often induce nausea and sedation, and tolerance occurs in some patients. Recent research has made it clear that CB1 receptor agonists act on pathways that partially overlap with those activated by opioids but through pharmacologically distinct mechanisms (see chapter 2). Therefore, they would probably have a different side effect profile and perhaps additive or synergistic analgesic efficacy."

http://www.nap.edu/openbook.php?record_id=6376&page=R1



"Cross tolerance has been demonstrated between delta-9-THC, delta-8-THC and its synthetic analogues. Cross tolerance, has not been demonstrated between THC and lysergic acid diethylamide (LSD), mescaline or morphine (McMillan et al., 1970)."

http://www.druglibrary.org/SCHAFFER/Library/studies/nc/nc1d_8.htm

"Morphine and delta9-tetrahydrocannabinol (THC) produce antinociception via mu opioid and cannabinoid CB1 receptors, respectively, located in central nervous system (CNS) regions including periaqueductal gray and spinal cord. Chronic treatment with morphine or THC produces antinociceptive tolerance and cellular adaptations that include receptor desensitization. Previous studies have shown that administration of combined sub-analgesic doses of THC+morphine produced antinociception in the absence of tolerance. The present study assessed receptor-mediated G-protein activity in spinal cord and periaqueductal gray following chronic administration of THC, morphine or low dose combination. Rats received morphine (escalating doses from 1 to 6x75 mg s.c. pellets or s.c. injection of 100 to 200 mg/kg twice daily), THC (4 mg/kg i.p. twice daily) or low dose combination (0.75 mg/kg each morphine (s.c) and THC (i.p.) twice daily) for 6.5 days. Antinociception was measured in one cohort of rats using the paw pressure test, and a second cohort was assessed for agonist-stimulated [35S]GTPgammaS binding. Chronic administration of morphine or THC produced antinociceptive tolerance to the respective drugs, whereas combination treatment did not produce tolerance. Administration of THC attenuated cannabinoid CB1 receptor-stimulated G-protein activity in both periaqueductal gray and spinal cord, and administration of morphine decreased mu opioid receptor-stimulated [35S]GTPgammaS binding in spinal cord or periaqueductal gray, depending on route of administration. In contrast, combination treatment did not alter cannabinoid CB1 receptor- or mu opioid receptor-stimulated G-protein activity in either region. These results demonstrate that low dose THC-morphine combination treatment produces antinociception in the absence of tolerance or attenuation of receptor activity."

http://www.ncbi.nlm.nih.gov/pubmed/17603035?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed

http://www.ncbi.nlm.nih.gov/pubmed/12606610?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/11445192?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/8138952?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/2997827?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/97703?ordinalpos=32&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

^That is all I asked for in the first place, was SOME ground to walk on, and he flipped a lid.

Either way, it's inconclusive, and it's already been stated that THC and Opiates have a synergistic effect.

If this was conclusive evidence, it would be a pre-requisite question before being prescribed opiates.

He stated that abuse of marijuana causes a tolerance to opiates, which isn't true. Thank you for that research though, at least someone can find something!

 

yeah, thats all I was pointing out is that there is no "definitive" proof yet.Thats why I hate these forums sometimes everyone thinks they are a damn guru, be humble and for arguments sake- BACK SHIT up at least even if its non conclusive.

 

People need to look at things OBJECTIVELY

It seriously just makes stuff easier, and everything starts to make more sense.

 

Since this thread has taken the negative route with personal attacks, it is now closed.
Please guys, all of you, let's keep the personal issues to private messages, calling someone a junkie is an insult and has only negative intentions behind which is obviously going to offend some people. There are no rules against expressing yourself here, but there are rules concerning personal attacks. If you feel you are being harassed by a member, report the posts, message a moderator, and please try and avoid responding to posts that only exist to instigate more pointless bickering.