What Drugs Don't Have Tolerance?

oops, i didnt realize this has been discussed so much

 

personal exp tells me that aid tolerane takes 4 days to be completely gone, but if i want to trip multiple days in a row, just keep doubling the dose each time. and as for the main question no drug ive tried has not produced a tolerance, ive never heard of reverse tolarance either, so im guessing i dont have that

 

I been smoking crack for the best part of a decade and my boyfriend for the best part of twenty years. Sometimes we both say to eachother that the drugs don't seem to be working in the same way for us but actually, it's just that the quality these days ain't what it used to be. When we do score some decent work it hits us the same way as it always has done. There's virtually no tolerance. I mean, sure, when you first start smoking you take longer gaps between pipes than you do after ten years but I wouldn't really say there's a tolerance issue. Crack is crack.

 

everything has a tolerance.. that's why its best to switch it up every now and then...

 

I definitely have a reverse tolerance with 2C-I and 2C-E

 

all drugd do

 

drugs**

 

simple edit would have suffice...

Heroin.. heroin has no tolerance whatsoever.. go do it!

 

despite anecdotal evidence of most regular tokers, i don't think THC has a tolerance.

 

I agree with this.

 

http://www.marijuanalibrary.org/brain2.html

I tried to find 'scholarly' articles but I can't be arsed to read through all those abstracts right now. There's a reason science relies on a diligent method and not strictly on people's perceptions.

 

That article says there is a tolerance to marijuana. It says it many different times. It just states that the tolerance to marijuana is different to the tollerance of other drugs.

 

I believe all the major recreational drugs produce tolerance, as well as drugs like caffeine and nicotine. Drugs like crack build up massive tolerance over relatively short periods, like using for a few days in a row, while drugs like pot build up a moderate tolerance over long periods, like weeks of daily use. Psychedelics like lsd or mushrooms produce complete tolerance after just one use, however it goes away in a couple days. I have used salvia twice in one day though, and got effects both times. Its really the way drugs work that makes it cause tolerance, ie acting on receptors in the brain. Even non psychoactive drugs produce tolerance.

 

good, Ive got 230 mg left cold chilln

 

anyone care to elaborate on the reverse tolerance of 2ce? i think it just has "normal" tolerance - similar to acid. if you try to trip again the same day you have to take more, not less.

 

Reverse tolerance in the sense that the second time you try to trip on the same amount, you trip harder.

So let's say I take 20mg one night, and then 20mg next week, I'll have a stronger trip the second time.
That's what I've found at least.

 

but if you take 20 mg the next day you won't trip as hard. not a great idea to trip 2 days in a row anyways. i guess i always increased the dose each trip, so i wouldn't have noticed that. i think the "sweet spot" is like 17 mg. 20 is too much for me - in that the negative effects increased more than the positive

 

try some cyanide

 

every single one does

 

If you are a heavy drinker daily, you refrain from getting the side effects? Is that Reverse Tolerance?

 

Well, the reverse tolerance doesn't kick in right away. It's like once the tolerance that makes you need more goes away, less will make you trip harder. If that makes sense.