my somewhat educated guess as to the long term dangers of RCs + psychs in general

Remind me not to come back to this thread and read it. I'll think about this stuff too much and ruin my next trip. No trips a bad trip but I like to have "fun"

 

ideally you should be in a position as a person that you can both trip and be aware that you might have to pay for it. i mean, it's worth it, isn't it?

 

Especially if it aborts migraines and stops headaches? Assuming something works like LSD or DMT or mushrooms maybe.

 

idealy, yes

but i worry that someday i'll be older and have brain cancer or something, and at that time i'll think, boy it was stupid to be tripping all the time

so that's why i'm saying like a 4 times per year thing
and they probably aren't THAT bad either

 

then the solution is to decrease the quantity of your trips and increase their quality

quality is a function of many things, but one of the most important is dose. You can either take a hit of acid every weekend your entire life and not learn a god damn thing and have mad HPPD or you can eat 1 heroic dose ever and get the whole package in one go.

 

well i said somewhere (another thread?) that i'm gonna try to keep my trips to 4 times per year (once per season)
i don't think i'll increase the doses too much, b/c i'm mainly talking about RCs (2ce, 2cb to a lesser extent, or 4homet maybe)
20 mg of 2ce is more than enough for me. maybe i'd go 25, but def no higher than that.
i have a 30 mg dose of 2cb, but that's all i have
and with RCs in general, i don't want to push the doses when a modest one does the job. i have QUALITY trips with 17 mg 2ce

now if i could find acid!...sure i'd probably take 3 or 4 my first trip. most i've ever done at once was 3, and that was with some tolerance. probably 2 with no tolerance. they were pretty good by other people's standards (and my own)

 

just wanted to bump this thread

and an update: i've tripped 6 times since my last response
3 times on 2ce
twice on L
and once on 2cb

so not exactly keeping it to 4x per year...but less than i was last fall. i tripped 9 times from nov. 1st to jan. 31st. so like 3 times a month. not THAT much, but i think that's what gave me the negative effects i was describing.

i'm gonna try to not trip again until friday november 13th (10weeks from my last trip) or the beginning of december (about 13 weeks)

and try to follow writers advice and go for a large, quality dose
well medium large - like 3 hits of L or 17-20 mg 2ce

 

When I was tripping on 4-aco-DMT I realized fuck body. Mind and soul are what matters...

Alcohol and cigarettes are way more harmful than practically all psychedelics so tripping once or twice a week and not always on same substance is just fine...

Many people tripped hundreds of times and they are perfectly healthy...

It's bad for your body to breath polluted air, it's bad eating most of the food, to get in touch with many materials, etc.. Most thing we use nowadays are not healthy...

I believe most psychedelics are healthy... And healthy mind brings healthy body..

Also I think it was way more harmful for my body smoking a pack of cigarettes a day than if I would trip every few days...

All in all, unhealthy and psychedelics practically never belong in same sentence... Keep word unhealthy for alcohol and cigarettes..

Don't worry be happy ...

 

i don't think it's quite that simple

i agree that other drugs are probably more harmful than psychedelics, but i doubt that psychedelics are physically healthy

 

I think some are, specifically those that at low dose help medical issues like stopping migraines and preventing them in the future.

 

ayahuasca is damn healthy.
http://www.nationalgeographic.com/adventure/0603/features/peru2.html

it increases the number of serotonin receptors on cell surfaces. shamans in the Amazon will drink it at least once a week (sometimes 4 or more) for over 40 years of their life. you see a lot of 80 or 90 year old shamans sitting with the young ones. oh yeah and they smoke mapaccho like its a goddamn oxygen stick.
Ayahuasca, Huachuma, and Peyote are really good for you. Each one has medicinal and nutritional value that surpasses many of our modern substances.

 

i think it's only healthy to increase the number of serotonin receptors if you naturally lack them. like if you suffer from depression or anxiety. so yea i'll admit that ayahuasca is probably better than pharms to treat those conditions, but not exactly healthy.
i also agree that they (ayahuasca, peyote, mushrooms? [BTW, what's Huachuma]) can't be THAT bad, evidenced by the old people that are still alive after using them like crazy for years.

i guess i'm thinking of acid and rcs (mainly 2ce in my case).
but it would hold true for mescaline, DMT, psilocin, etc etc
all these drugs activate

the 5HT2A receptor, which is not only expressed in neurons, but in

• Blood Vessels - caused vasoconstriction
• GI Tract - causes contraction
• Platelets - aggregation
• Smooth Muscle - contraction

so not only can these drugs cause weird molecular changes in your brain, they can do it throughout your body. just to illustrate one example...

HT2B receptor stimulation, achieved by DOxs and MDA/MDMA, "can also lead to pathological proliferation of cardiac valves fibroblasts,[6] which with chronic overstimulation of 5-HT2B can lead to a severe valvulopathy. Moreover, 5-HT2B receptors were recently shown to be overexpressed in human failing heart and antagonists (the opposite effect of agonists like DOx/MDMA) of 5-HT2B receptors were uncovered to prevent both angiotensin II or beta-adrenergic agonist-induced pathological cardiac hypertrophy in mouse.[7][8][9]"

i couldn't find any specific shit on acid, 2ce, mescaline or dmt, but chronic overactivation of these receptors can't be good.
LSD activates 5 subtypes of serotonin receptors..

5ht2a activation increases cellular levels of IP3 and DiAcylGlycerol
Diacylglycerol can be mimicked by the tumor-promoting compounds phorbol esters.

that means tumor promoting molecules mimic (and have similar downstream effects as DAG)
LSD activates 5ht2a, increases DAG, leads to signals for cells to grow -----> get brain tumor???

 

Well activation of the 5HT2A receptor has links to stopping suicidality as well as migraines, so that might be worth it.

And maybe because affects the GI tract that's why my IBS was helped when on 4-aco-DMT which is active at the 5HT2A receptor.

 

MAYBE
it's all a big huge one

but i'm pretty sure i did some reading yesterday about over stimulating some or one of the 5HT receptors CAUSES anxiety and depression...which is responsible for some of the negative effects of LSD

this was all at wikipedia under the 5HT receptor
but more of it was from 2ce's page. go to serotonergics and expand that box. you see all the drugs that are agonists or antagonists at each serotonin receptor. then you can click on the receptor and learn a LITTLE about it. not much seems to be known about them. especially activating multiple ones with different affinities.

and no disrespct xanonimity, but you are obsessed with the migraine stuff
i guess i would be too if i got them..so really no disrespect

i think a lot of AGONISTS were meds used to treat suicidal tendencies, depression, anxiety, etc. i could be wrong about that though
not to patronize, but if anyone doesn't know
an agonist mimics the natural ligand's effects at the receptor
so LSD for example mimics the effects of serotonin
therefore it's an agonist
another drug (antagonist) binds to the receptor but doesn't have the same effect as an agonist. it blocks this effect by binding to the receptor.
so you MIGHT wanna look at antagonists to help with your migraines and stuff
but don't quote me on that last part

 

How can you even care about it, even a little.. Do you watch label on everything you buy, cuz most of it is toxic... Do you grow your food... Do you use cellphone... Do you stare in TV or PC for hours... Do you live in town... Do you stay longer than 30mins on sun... Do you live?

If any psychedelic is causing you any harm it's minor opposite to alcohol and cigarettes.. And if there are some psychedelics that may cause some degree of harm are still giving you more than harming you...

Yesterday near the end of trip I remembered your words... Wtf are you talking man... No psychedelic is that bad for you and if you get brain cancer and blame some psychedelic for that... fuck it... it's all part of cosmic trip... and you wont.. taking psychedelics is safer than walking down the street and you know it ...

Also there is limit for tripping below you don't want to go... Tripping too rare is bad for you... Trip man, just trip .

Better ask your self what is the real reason you want to trip rare, is it worth ...

Life is a trip... But trip is beyond life...

Peace...

 

^^thanks for the advice man

 

Hope you really mean that ...

Man I'm different person than 3 days before... Everything seems so much more simple, but in absolutely positive way... Like I don't have anything to worry about but still I will do everything to make things batter ...

 

Well said. Though Rc's seem to have gave me Hppd. Never had it till started trying out synths and dxm.

What if you live near a microwave/ or radio tower. They have a warning on them that if you even touch them someone can get severe Radio frequency burns...=radiation burns. Cell phones don't help much either as well with everything else.

If it will expand my mind and have a good experience. I probably won't turn it down or at least giver her a try.

 

One thing is certain: the risk of negative outcomes of any sort increases with high and frequent dosing.