Numericals

Discussion in 'Opiates' started by kiddydope-z, Jul 12, 2009.

  1. kiddydope-z

    kiddydope-z Member

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    As I was looking through the 107 pages of opiate threads, i noticed theres no thread dedicated to opiate conversion.. I don't know how accurate my information is, however I've started a file on my computer about 6 months ago dedicated to pharmaceutical conversions.. thought id share with you all :)


    Wikipedia:

    30 mg of immediate-release morphine by mouth is similar in analgesic effect to 7.5 mg of hydromorphone by mouth, 10 mg of morphine by injection, and 1.5 mg of hydromorphone by injection. These doses also correspond to about 30 mg of hydrocodone, 24 mg of oxycodone, 200 mg of codeine, 135 mg of dihydrocodeine, 20 mg of dihydromorphine, 15 mg of nicomorphine, 12 mg of heroin, 34 mg of piritramide, circa or about 18 mg of ketobemidone, and 8 mg of dextromoramide by the default routes of administration and 60 mg of extended-release morphine via the oral route.

    My interpretation:

    30 mg immediate release morphine orally = 7.5 mg dilaudid orally = 10 mg morphine IV = 1.5 mg dilaudid IV = 30 mg hydrocodone orally = 24 mg oxycodone orally = 200 mg codeine orally = 12 mg heroin IV = 60 mg extended release morphine orally


    I also came across opiates' bioavailabilities..

    Methadone- oral 84%
    Hydromorphone- (5-8 times as potent as morphine) intranasal 52.4%, Rectal administration 33%, Oral 30-35%
    Heroin- oral 35%, IV 100%, IM 85%
    Fentanyl- transdermal 92%, sublingual (against cheek) 50%
    Morphine- oral 30%, insuffulated 15-20%, Chitosan (a linear polysaccharide that helps absorb drugs better) has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%
    Oxycodone- oral 60-87%, intranasal 55-70%
    Oxymorphone- nasal 43%, oral 10-20%
    Codeine- oral 50-84%


    Enjoy! Feel free to challenge any of these numbers. Like i said, i could be wrong.. this isnt wrote from personal experience but from years of research.

    :cheers2:
     
  2. SpENS93

    SpENS93 Illuminati

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    u looked through 107 pages o.0
     
  3. Verisimilitude

    Verisimilitude Member

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    if you google opiate conversion or narcotics conversion chart you should find a really kick ass informative chart that shows the conversion rates (very close to what you posted KDz) and a bunch of information about each drug. There's also a chart like this for benzos. They are made by the Canadian health department I think.
     

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