I'm starting this thread both to inform people with no knowledge of potentiators and in hopes that there is someone out there that can chime in with new ones that I don't know of. For those of you that don't know, potentiators are substances that will make your DOC stronger, specifically regarding opiates in this forum (obviously). Known potentiators (by me) #1. Grapefruite Juice (specifically white, ruby red will work but not as well) Grapefruit juice contains a liver enzyme inhibitor, meaning when your drug makes it's first pass (assuming you go through the oral route, and also if snorted since much of it will also go into your stomach) the enzymes in your liver responsible for breaking the substance down are inhibited, and do not work as well. Believe me, this works. I would say it will make your DOC at least 25% stronger when drinking grapefruit juice before and after dosing. Some claim it doubles the dose, but I find this simply not accurate. In any case, be careful. I would not advise taking your average dose with grapefruit juice. The pharmacies have caught on to this too. Now whenever you fill a scrip for oxy (or whatever) it might not just say "avoid alcohol" but also "avoid grapefruit juice". Anything to save them money right? (Note: This also works for benzos) #2. Marijuana I've read in various places that many users do not profit from marijuana smoking while on opiates, and for this reason I'm listing it as number 2. But every person I personally know will agree with me on this one. In fact it's not even worth it for me anymore to take my average dose of whatever opiate is available if I have no weed to go with it. I wait until I'm peaking off my DOC and then smoke a bowl, and that I WOULD say doubles the effects for a short time, again, for me at least. #3 Benzos Any benzodiazapine will enhance your opiate high. But with my personal experience, it doesn't necessarily enhance the opiate itself, as with the previous two examples, but intstead adds another element to the high. Very pleasant. #4 Alcohol Alcohol of course is the standard for potentiating a great number of drugs, including uppers and downers, but I personally stay away from it. I used to take a shot of whiskey before taking my fix, but I've found that it's not worth it, and really doesn't add anything to the experience. Not to mention that alcohol constricts your blood vessels meaning your DOC has a harder time reaching your brain. And of course this is possibly the most dangerous potentiator. #5 DXM (robotussin) This is not exactly a potentiator in the sense that it enhances the effects of your opiate, but what it DOES do is lower your opiate tolerance. I've got you interested now don't I? I've not personally done enough reading to explain the mechanisms of how it works, but I would think (just a theory) that taking a small amount over time (a week or so) would work better than taking some along with your opiate dosage. (Note: DXM has also been proven to alleviate opiate withdrawal symptoms) #6 (rumored but not proven, as far as I know) Acetaminophen (Tylenol) I remember once reading that acetaminophen will potentiate certain opiates (hydrocodone and oxycodone come to mind, perhaps codeine) but I can't seem to find any more information on the subject. Anyway it wouldn't hurt to eat a couple tylenol along with your opiate, unless you have liver problems then you should stay away from it. #7 (A strange exception) fatty foods (with oxycodone). I read from two different sources (because I was skeptical at first) that foods high in fat eaten before Oxycodone ingestion will increase rate of onset by approximately 30%. It didn't say anything about any other opiate, only oxydone (but it was directed at oxycodone so this does not necessarily omit other opiates as well). I prefer to take my opiates with an empty stomach, so I simply eat a spoonful of butter 10 or so minutes before hand. Assuming I haven't forgot anything, that's all I know of personally. I once did all of the above with half of my normal dose of oxy and in 20 minutes was puking my guts up because I was so fucked up. Anyone with any information to add would be greatly appreciated.
Cimetidine (Tagamet) is a potentiator also. I actually just learned about this, and tried it with a cold water extract of hydro 7.5's about two hours ago- well I tried the white grapefruit juice and Tagamet pill and smoked a few hits of some bomb kush, not all the other shit... Love it
Well Tramadol is a weak opiate in itself, so it makes sense that it would make stronger ones even stronger. I forgot about tagamet, probably because I don't use it. It's been proven to decrease brain function so I stay away. Good addition though.
fatty foods do work i'm pretty certain. have some really greasy standard fast food and blow some lines you'll be more rocked than if you had an empty stomach i think.
what about Proglumide ? I can't afford going to all the doctors it requires to increase my 5x10mg hydro medicine.
I'd never heard of that Glen, but looking it up it sounds like it prevents your tolerance from going any higher. Sounds pretty damn nice to me. But it also says that it's not in circulation anymore, but if it exists I'm sure it could be found. Maybe mexico or something.
Gotta go Benydryl, Naproxen (Aleve), White Grapefruit Juice, and opiates on empty stomach. Its hard to beat, and of course a small dose of Benzos and or weed if avalible.
