so in some of the potentiation recipes i've seen, it is suggested that you use tums or a similar acid reducer in addition to white grapefruit juice if you're taking your dose orally. obviously it has to do with balancing out the ph levels, but is this necessary? is the drug destroyed or anything by the acids if you don't take tums? i'm just asking 'cause i have GF juice but no acid reducer, so i'm wondering if i'm good to drink it anyway if i don't really have to worry about this step.
I've heard lots of stuff about grapefruit juice potentiating stuff just on its own. Normally I'd dismiss something like that but loads of the medication my dad has just for blood pressure and shit does actually say 'do not drink grapefruit juice with this medicine' so there is something chemically unique about it. So the tums thing prob isnt necessary. Off to Wikipedia i go!
drank the GF juice about an hour and a half ago, also poppsed most of a benadryl, maybe about 20mg, and took about 30mg or so of DXM. swallowed 12.5mg of oxy about 30 minutes ago. annnnd, uhh... tums was not necessary actually lemme just say... it should really go without saying but i'm so glad i started with such a low dose. i was gonna snort some more but i'm so glad i waited, i'm already high as fuck and i only took 12.5mg. this is also with no tolerance. i just want to stress that you really shouldn't underestimate potentiation, it makes a pretty big difference. edit: haha fuck. i dunno if you guys remember when i said that i didn't like oxy all that much... well, i take it back.
haha shiiiit. i dosed my oxy last night starting at 2 45 AM by swallowing 12.5mg. i chilled and snorted bumps casually over the next few hours until around 6 AM, bringing my total to 25mg. woke up today, it's now 11 20 and i'm still kinda high and my eyes are still pinned. this is lasting a looong time.
When you take opiates orally, some will be broken down by the liver and processed by the kidneys into your urine. The portion that makes it to your brain via being absorbed into the bloodstream is what makes you high. Drinking grapefruit juice will inhibit the P450 enzyme (produced by the liver to metabolize opiates (amongst other things)). By doing this you increase the BA of the drug, causing you to feel a more intense and longer lasting high. Be wary though, for if you attempt this while taking larger doses, you risk ODing.
Apparently this doesn't work for morphine-based opiates. So oxyand methadone. It also works for codeine cause codeine does not actually get you high because of the morphine to which it metabolises. I remember reading that somewhere, can't remember how it does work...
It will work for all opiates and many other drugs for that matter. Some medications even have warning labels on the bottle that recommends that you do not drink grapefruit juice while taking the meds. http://en.wikipedia.org/wiki/Cytochrome_P450#Drug_metabolism Follow the link for more info ^^
"Morphine itself, however, is not affected by grapefruit juice, as it is not metabolised by the cytochrome P450 system."
Yah that's what I said. Doesn't affect morphine. So won't help you metabolise hydrocodone, morphine, H, etc...
people swear that it does nothing, yet I believe it does, makes your buzz hit a little harder and last a little longer.
it definitely worked for oxy, no question. i swallowed 12.5mg and snorted 12.5mg... was nodding the fuck out. in the past 20mg has been really good but not close to this, and i doubt 5mg made such a huge difference. this is all with no tolerance of course.
Thanks for the info. I had no idea lol i always do the grapefuit before any of my opiates. Guess i dont have to keep doin that...although grapefruit is delicious!
I take a med for cholesterol, and on the bottle is a warning to not drink grapefruit juice while taking it. I asked my doctor about this, and she said that grapefruit juice increases blood levels of the med (Simvastatin). So I suppose it could work for pain meds as well.
I did some research a while ago. Said that taking 60-120 mg of dxm about a half hour before taking the opiate, then chewing 2 tums at the same time you take it makes it last longer and stronger. also grapefruit juice does something with the metabolism of the liver and increases intensity of the high so drink it after u dose. Also heard tagament helps too
yeah tagamet works the same way as grapefruit juice i think, just more effectively. there's a whole opiate potentiation thread somewhere on these forums. so helpful.
Thats what i said already. But you have to drink it about a half an hour BEFORE you dose. It would do anything if you drank it after.
ohh ok gotcha. Maybe it was just a plecebo then cause i drank it after dosing and felt an increase. but youre right next time ill drink it before.
Don't use white gpj. It's the bland, original Grapefruit Juice that works the best. And yes, it does work for some things, especially Valium. It inhibits a certain enzyme, I don't think it has to do with pH levels if I remember correctly... Taken from: http://www.erowid.org/chemicals/opiates/opiates_info3.shtml
ah yeah after i posted this i realized that the tums is just to balance out the ph in your stomach or something, which also helps to increase the absorption of oxy. when i read a potentiation guide i thought that the tums was related to the GFJ but it's not. 100% unsweetened white GFJ isn't all that fun to drink though haha
