I wonder if you were to block the opiate receptors of the GI tract with loperamide before dosing (because it can not cross the BBB it will stay within the GI tract), would you achieve a greater or longer high? I ask this because if the GI receptors are already being held by the loperamide would there be a greater volume of opiates reaching the brain? I don't know lol.
So i was trying to search for an answer online but couldn't find one at all. Anyone have any insight? It may just be a dumb idea but i'm just curious.
Coming from a studying biology student with a focus in cellular/molecular/biochem, that's a damn good hypothesis. Don't see why not.
Thanks, i just wanted some input before trying it and getting stopped up from the loperimide lol. It makes sense to me. Anyone else got an opinion?
I doubt this will have much effect. Bioavailablity plays a major part...so unless you can alter that, which I don't think this will, then you probably won't notice much besides placebo. Also, Loperamide is an extremely well known substance for people who take opiates, because of how it can help WD's...so I think SOMEONE would have figured this out by now. Also, I haven't heard that Loperamide blocks opiate receptors? Do you have more information on this? Not doubting you, just haven't heard any solid proof about that.
If an opiate binds to a receptor with higher affinity, then it essentially blocks any opiates with lower affinity. Think suboxone. The question is: Does loperamide have higher affinity for opiate receptors vs oxycodone? If it does, I really don't see how this wouldn't work. We know oxycodone already binds to the same receptors as loperamide since they have the same effect. If loperamide does have a higher affinity: then oxycodone won't be able to bind to those receptors in the gut where loperamide has bound and there will consequently be more oxycodone floating in the blood to bind to the rest of your opiate receptors - thus, loperamide acting as a potentiator.
Dear God, i could have put it any better myself! Thanks digdoug @ U4ia: Now that its been clarified differently, any input? Your intellegent as hell man. And i thought some one would have thought of it, that is why i asked you guys lol.
I know someone who might give it a shot depending on how things work out tonight. Won't be definitive testing but I'll let you know methods and results.
had a similar question i posted on opio last year. seems if the binding affinity of lope is higher you SHOULD have more dope left to go straight to the brain. lope is VERY potent though noone had a good answer on its specific binding affinity. my eh, subjective testing was hampered by living in a tent in santa cruz and only enough money to feed my dope and coke IV habit. good hypothesis, i had it meself once. awaiting conclusive evidence since i am clean aside from dxm in final stage of bupe w/d. oh yeah, hey, im thanat0s. sword and butterflies etc.
