its on her way :) :) :)

I got 3 pills comin here in like an hour . Yellow Keys. I searched em up n it said theyr MDMA n the reporter said he had fun off 1. soo wahoo only downside is Im alone tonite so I gotta find somethin to do while Im on it.

 

i hope you find something to do you're going to have a fun time !!

 

Yay! Do some coke with it. It will make you cum all over yourself and friends

 

Maybe save them for a night you're not alone?

 

I was going too, but w.e I watched the new star trek movie on em, trippy shit. werent that bad of pills kicked in at like 930 n lasted till 3 am. n as usual jus thinking about it now makes me kidna sick soo I know they where good

 

nice bro xD

 

i know you hate me and all but for real e + coke = your heart will beat the fuck outta your chest. horrible idea

 

If you know your limits it's actually an excellent combo, but ketamine and MDMA is where it's at.

 

i guess so...but who really knows their limits about coke..especially if your rolling?? ya know

 

mdma and coke compete for the same receptors in your brain, so they cancel each other out to a degree, so its a waste of both imo.

mdma and ketamine, now we are talking. k hole while rolling is truly cosmic euphoria

 

No way man! MDMA is an agonist of serotonin mainly. Even though it does effect dopamine receptors, because cocaine is a re-uptake inhibitor that would only make it stronger. The MDMA would release the small amount of dopamine and the coke would stop it from being reabsorbed. Coke just makes MDMA stronger to me, but way more euphoric.

 

cant wait for writers response

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2167630/

Well both cocaine and MDMA are reuptake inhibitors, so with this logic each should potentiate the other. Coke binds *equally* to dopamine, serotonin, and norepinephrine. MDMA prefers serotonin 10 to 1. By introducing both into your body, you make two molecules compete for a finite amount of receptors your brain. If you do coke first, the coke will take up n receptors, and so the MDMA will now have [brain -n] receptors to bind to, weakening its serotonergic effect. If you do the molly first, most of your 5-HT receptors will be taken up, and cocaine will release only DA and NE.

they will both potentiate the other through one shared mechanism, but because they both also share their "fuel source", its a dicey situation on paper. I imagine it could go either way, but you are the first knowledgable person I have heard to say this combo works. Everyone else says as soon as you do that line and you're rolling, the roll is killed and the line sucks.

It's also a pretty nasty combo for your brain and rest of your body but I wouldn't mind trying it one day.

 

DAAMMMNNNN doood! AWESOME. No one ever schools me! That felt good I love to learn. I didn't know that coke was a re-uptake inhibitor of all three! AND I didn't know that MDMA was a re-uptake inhibitor. I read that its action was from the antagonation of serotonin recetors with little effect on the others. Good read(s)! TY for schooling me

 

Yeah, I was right. That is an article on different analogs of cocaine. Please reference it. I don't know who wrote that paragraph that you referenced, but the reference was misinterpreted by the author.

"There also were those analogs (e.g., WF-23) with high affinity, but with equal affinity at all three transporters."

But it says before that, " those selective for only the DA transporter (e.g., WF-29)"

Here is one of a few articles I read about how cocaine doesn't effect the 5-ht receptors themselves, but rather through pre-synaptic neurons. (making them not compete for the receptor, MDMA and coke)

"In order to examine whether cocaine-induced behavioral sensitization is modulated by changes in serotonin receptor subtypes, we measured the binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) to 5-HT1A receptors and of [3H]-ketanserin to 5-HT2 receptors in various brain regions of cocaine-treated and saline-treated (control) rats. As previously reported, repeated administration of cocaine resulted in behavioral sensitization. Stereotypic scores with the cocaine challenge were significantly (P < 0.05) higher in cocaine-pretreated animals than in the saline-pretreated group. Neither acute nor chronic cocaine administration significantly altered the number (Bmax) or the affinity (KD) of either [3H]8-OH-DPAT or [3H]ketanserin binding sites in any of the brain regions examined. These results suggest that the enhanced functional sensitivity of 5-HT1A or 5-HT2 receptor subtypes seen with cocaine may be associated with alterations in processes distal to receptors rather than changes in the number or the affinity of the receptors." http://www.ncbi.nlm.nih.gov/pubmed/8405113

BUT I have also found this article http://www.grinnell.edu/academic/neuroscience/pn-v8/includes/Vallas_Yin_Salazar.pdf

I don't know what to think now. I have read in a few that cocaine is more selective for DA, but now it looks like some say it does and some say it doesn't. Either way, I know it feels good

EDIT I am talking about reference number 1 and 5.
EDIT again; It also says in the second to last reference that its only 5 times more selective.

 

From my experience lines never killed my roll.
But some people say weed kills their roll, so I guess it's one of those different strokes things.
As I said before coke and MDMA was quite a fun combo the two times I've done it.

 

What? It's not about analogues of cocaine, it's about cocaine and mdma. I linked to it under my quote. The title is "Effects of Cocaine and MDMA Self-Administration on Serotonin Transporter Availability in Monkeys"

I don't know where you're getting this from or the context.

Yeah the literature is confusing.

 

Yeah, my wife has a thing for me being on the computer for more than a little bit. She was bugging me to get off while I was reading that and posting the reply. I didn't get what I was trying to say out there as well as I hopped I was talking about the paragraph that you quoted;

The study itself that you reference (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2167630/) has flaws in it. I was suprised to see that coke has equal binding affinity to all 3 receptors. So to understand it more I click the reference for that to see why and how blah. Anyways, in the second sentence it say this;
"Cocaine increases synaptic levels of dopamine (DA), serotonin (5-HT) and norepinephrine (NE) via blockade of the presynaptic transporters (DAT, SERT and NET, respectively; http://www.ncbi.nlm.nih.gov/pubmed/7891330, 1995)."

The link (titled "Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain.") says this;

"A novel scheme utilizing vinylcarbenoid precursors has been developed for the synthesis of tropane analogs of cocaine. Specificities of these compounds for dopamine (DA), serotonin (5-HT) or norepinephrine (NE) transporters were determined by both uptake inhibition and binding assays. In each of the analogs, the aryl group at position 3 was bound directly to the tropane ring (as in WIN-35,428), and methyl or ethyl ketone moieties were present at position 2 in lieu of the ester linkage present in cocaine. The addition of methyl or ethyl ketone groups in position 2 did not affect potency compared to ester groups in the same position, but substituents on the benzene ring greatly affected potencies. The analogs could be categorized according to their relative specificity, which consisted of those selective for DA and NE transporters with little affinity for the 5-HT transporter (e.g., WF-39), those selective for only the DA transporter (e.g., WF-29) and those selective for the 5-HT transporter (e.g., WF-31) with much less affinity for the DA and NE transporters. There also were those analogs (e.g., WF-23) with high affinity, but with equal affinity at all three transporters. The analogs displayed significant correlation between uptake inhibition and binding displacement at DA, 5-HT and NE transport sites. These results suggest that large variations in the tropane structure do not result in a differentiation between binding at biogenic amine transporters and inhibition of amine uptake."

So not only is the first reference invalid because of the study on analogs and not cocaine itself, so is the fifth one that says this, "Cocaine binds with relatively equal affinity at all three transporters (Bennett et al, 1995)". That same reference goes on to say this as well though, "The analogs could be categorized according to their relative specificity, which consisted of those selective for DA and NE transporters with little affinity for the 5-HT transporter (e.g., WF-39), those selective for only the DA transporter (e.g., WF-29) and those selective for the 5-HT transporter (e.g., WF-31) with much less affinity for the DA and NE transporters. There also were those analogs (e.g., WF-23) with high affinity, but with equal affinity at all three transporters."

I guess what I am saying is that the whole study confuses me. When I look for other references they have conflicting information. Most of them though say that its action is through distal receptors and not at the binding site specifically.

Now I need to try it again and pay attention to the effects. Its pretty possible that there was a placebo affect and I just wasn't paying attention. Guess I will have to wait and see Let me know if you find out anything.

 

noob scientists imo

 

I've done it, all i know is I felt good, dunno what I was feeling though. I was kind of in a panic state, I had just blown a few lines and then this kids parents come in and start accusing him of stealing from them and using it on drugs (which he did) and I thought they knew we were on drugs right then. Ruined my night thinking they were gnna call my parents and shit.