Chlorohuasca? [2c-c+syrian rue] What will happen?

So the one think i like about this time of year is that all of my friends that have moved off, away from my town come back for the holidays. which means it's unfortunate that my stash is pretty depleted...

Tonight, i was going to split the last of my 2c-c with a close friend who is back for the holidays. He has some Syrian rue, so i was thinking it may be a good time to utilize that.

i've found some conflicting information regarding the effectiveness of MAOI's potentiality 2c-x compounds. I've had trouble finding information on 2c-x + Syrian Rue. One person on a bluelight thread said that the enzymes 2c-x compounds are metabolized by are not enzymes which Syrian rue will effect?

i've found virtually no substantiation on any this, and reports of the combos were hard to find, and varied significantly.


DOES ANYBODY HAVE PERSONAL EXPERIENCE ON THIS? I'll probably at least smoke some of it while peaking on the 2c-c and see what happens, because it doesn't seem to be a dangerous combo.


Chlorohuasca here i come!

 

2c-*'s are amines. It should potentiate it.

If it can be salted (furmarate, hcl, hbr, etc.) and ends with the word "amine" then it should be broken down by MAO (MonoAmine Oxidase). (phenethylAMINE, meaning there are three groups in this chemical. Its base being an amine. Phenyl, ethyl, its paired to make a amine)

This is my take on the situation. Let more experienced people say though first.

 

Ok...thank you Codmouse. I've read a lot of conflicting data.

I actually am currently coming down off of the 2c-c [no syrian rue].

got the fuck out of my town, went to the city and danced for like 3 hours with the girlfriend...i feel perfectly sane afterwords. i love this compound

 

I think I we seen serotonin syndrome reports with 2c-e / 2c-i + maoi.

Not sure about that, so check it ok?

 

Yea, i didn't intend to take a dose of it unless people had alot of experience. Just an idea i had...I said i was going to anyways in attempt to prompt more responses, because in truth MAOI's scare me a bit.

i think i'll save the rue for a while...maybe take some by itself and smoke the last of my 5-meo-dmt...though that combo is supposed to be an "off the deep end" type of thing.

i wish i had some more 4-aco-dmt, because that + syrian rue sounds fucking amazing.

 

We have two kinds of MAO, MAO-A and MAO-B. Harmaline and the other compounds in Syrian Rue are principaly inhibitors of the MAO-A. Phenethylamine are mainly broken down by MAO-B. So Syrian Rue will not influence the metabolism of the 2c-x compounds. They won't be a special influence.

But the Rue have some effects by itself. So the combo Rue+2c-c would have more effects than only 2c-c. Understand?

And sorry for my fucking bad english... I speak french normaly...

 

THANK YOU!!!!

i don't know how i didn't uncover that in my research...that explains a lot.

[and your english is fine ]

 

TY! for the valuble info!!! I really love learning things that I don't know. Alllll mighty king kong!

 

i hope that guy keeps posting...it's always good to have a chem major around! :groupwave:

 

Yeah guy is right:

Wiki:
There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Dopamine is equally deaminated by both types.

Syrian rue is non selective, aka both MAOI A and B.

 

I am going to try SR with 5-meo-mipt at a low dose to see what it does. Maybe it will make a dose -10mg psychedelic...

 

i really can't wait to get more 4-aco-dmt so i can do like 15mg oral and a few grams of sr...it sounds amazing.

 

more true that you would think lol

 

that doesn't add up
you guys aren't saying the same thing

 

i think what that means is that Rue is mostly active on MAO-A?

 

Maybe. It says it's active on both, but more on MAO-A.

Sorry for confusion guys.

 

OK...

that actually seems to go along with what i've read about 2c-x + syrian rue...doesn't seem to potentate much but definatly makes the trip different..

 

Rue and Harmala are principally MAO-A, only very minor MAO-B. that's why dietary restrictions don't apply 100%.

 

Nice, nice man.

 

one of these days i'll try it.