certain drugs have opposite effect on me - anyone ever heard of tihs?

I've been a casual weed smoker for about three years now, but I never had the 'love' for the plant that many others tend to. There are many effects of marijuana that I enjoy, but there are also those that I don't like...


Marijuana never fails to give me anxiety or a paranoid feeling at least SOME TIME throughout my high...which is why I have been steering clear from it more so lately because I have been beginning to wonder if the anxiety is really worth it.

Also recently I have been experimenting with adderall and vyvanse. It seems that people claim that these drugs give people massive anxiety and paranoia and often times a horrible comedown. I get none of these negative things when I take amphets, and I really enjoy them. I just think its strange how the some of the reasons people smoke weed (a relaxed state clear of stress) does the opposite to me, and I achieve this effect my taking adderall while doing so makes others very anxious. Anyone ever heard of something like this, or have any idea why my brain responds to these drugs in these ways?