anyone can explain this ? its about 5-HT receptors (which interfere in mdma, lsd, dmt use), MAOIs and serotonin. [FONT="] [/FONT]"5-HT1A receptor activation likely plays a significant role in the positive effects of serotonin releasing agents (SRAs) like MDMA as well. Other effects of 5-HT1A activation include decreased aggression or increased serenic behavior, increased sociability, increased impulsivity, facilitation of sexual behavior (common for mdma use)." [FONT="][/FONT][FONT="]"[/FONT][FONT="]antidepressants (MAOIs) build up in the bloodstream and the serotonin level is increased, it is common for the patient to feel worse for the first weeks of treatment[/FONT][FONT="]. One explanation of this is that 5-HT1A receptors evolved as a saturation signal , telling the animal to stop searching for food, a mate, etc., and to start looking for predators. In a threatening situation it is beneficial for the animal not to feel hungry even if it needs to eat. Stimulation of 5-HT1A receptors will achieve that[/FONT][FONT="]" After a while (2-3 weeks) the number of 5-HT1A receptors decreases through a process known as [/FONT][FONT="]downregulation[/FONT][FONT="] and the animal goes back to its normal behavior. [/FONT][FONT="]This suggests that there are two ways to relieve anxiety in humans with serotonergic drugs: by blocking stimulation of 5-HT1A receptors or by overstimulating them until they decrease via tolerance[/FONT]" there is a contradiction (underlined) which i cant explain also i have a hard time explaining this (which i think is the most important part) Maybe someone can put the following in other words? "[FONT="]Unlike most drugs that elevate extracellular serotonin levels like the MAOIs, SRAs such MDMA fully bypass serotonin autoreceptors like 5-HT1A by forcing release to occur regardless of their inhibition"[/FONT] [FONT="]"Sufficient doses of 5-HT1A receptor agonists themselves, like SRAs, are capable of fully bypassing the 5-HT1A autoreceptor-mediated inhibition of serotonin release and therefore decreased 5-HT1A postsynaptic receptor activation as well, by directly agonizing the postsynaptic receptors in lieu of serotonin[/FONT]" i dont know if these questions seem foolish to you but im just trying to figure out how this things "work". im interested in this receptor particulary because it is linked to lsd, dmt and maois. [FONT="][/FONT][FONT="][/FONT][FONT="] [/FONT]
It sounds contradictory because it's explaining that mood regulation is not as simple as too much or too little serotonin. The passage describes how overstimulation of 5-HT receptors can cause anxiety, it uses the model for motivation in eating and looking out for predators to exemplify it. They describe an effective method is to overstimulate the receptor until you get downregulation(lessening in the amount of receptors) or blocking stimulation leading to normal transmission. I'm going to assume you have a basic knowledge of chemical synapses and how they work in signaling, for this just know presynaptic and postsynaptic, and what an agonist is. If not wikipedia basic pharmacology and look up those concepts. When you have a large initial increase in serotonin/5-HT agonist in your synaptic cleft you have activation and eventually saturatoin of your postsynaptic receptors and your presynaptic receptors this is due obviously to the large amount of compound available for binding. The binding of the autoreceptor inhibits the release of serotonin into the synapse (this is refered to as a negative feedback loop).Overstimulation of autoreceptors causes downregulation, ergo decreased sensitivity. MDMA still causes the release of serotonin despite the autoreceptor binding, ergo you get the immediate response. I think your confusion stemmed from misunderstanding the role of an autoreceptor. I hope I explained that well enough, the pharmacology of it is more convoluted but not relevant for this discussion.
thank you very very much! this passage elucidated completely the things for me. so easy now! you were right, i misunderstood the term "autoreceptor" but i totaly understand now...Its all about the negative feedback i was familiar with the other terms...Just this one (autoreceptor) does not exist in my language (we use another term instead) so i tought it ment something else. sometimes studying in other language isnt that easy. thanks again!
Mechanistically/physiologically theoretically it should help your comedown. People anecdotally say it helps them and there isn't any harm after you roll. I personally never have had issues with the comedown so I've never tried 5-htp. Try it if you want, no harm in it...
I regularly take 5-HTP following my rolls & from someone who has frequently fried up the majority of natural serotin on xtc "binges", it helps me a lot. I also am on cymbalta for depression, so I already have some issues there to begin with, but being that 5-HTP is cheap & easily available it is worth trying out. Hope that helps! And most of my friends who roll w me usually bum them from me the next day or days following, and they say it helps them too!
I bought them, but it didn't really help my attitude. I get so bummed out the week after rolling. Ugh.
