4-DBT and its Companion OxyNitro 3-DBT

Can I get some just discussion on what might involve the steps to analyzing these two chemicals for activity involving the stereo chemistry of the 5-HT2a receptor. #

The first is called 4,-DiethylamideBaseTryptamine. (4-DBT)


The way I view the stereo chemistry of the 5ht2a receptor is limited to a tetrahedral structure called a Truncated icosahedron. #

Salvinorin A #
is a kappa opioid receptor agonist. This has a tie to the action of the Sigma 1 receptor #

Next is
(3-OxyNitro DiethylBaseTryptamine)


So just looking for conceptualizations based on the chemical structure and the geodesic chemistry theories I have.

-the chemicals that all alter the 5-HT2A receptor with non toxic means and are vastly effective synthetically and organically can be drawn in theory on a truncated icosahedron.

Using this as a potential model of a truncated rhombic triacontahedron. You could in theory estimate the outcome of ingesting this potentially white crystalline solid.

I had a theory that the endoplasmic reticulum using its Ca 2+ ions would transfer distortions by the sigma 1 receptor. Through resonance with the Kappa Opioid Receptor and the 5-HT2A receptor, to access the nucleus of a cell and alter through means of consciousness your own DNA.

 

My current method of mapping the chemicals that already play a role in consciousness in a mathematical way.

6 = carbon, 7 = Nitrogen, 8 = Oxygen.

________6
__6_______7
6___6___6___6
6___6___6
__6___6
__7_-_6

This is DMT in simple form just numbers no bond info.

its set up in sets of 2 numbers alternating like this

6___6___6
6___6___6
__6___6
__6___6
6___6___6
6___6___6
__6___6
__7_-_6

I am trying to do a simplified way of understanding chemical polarity. I need to make a map of the differences in chemical structures and their roles in normal human awareness, and how it is alters like a cable of flowing information being bent in different directions. causing distortion patterns on a receiving monitor and cross firing circuits that do not damage the computer, merely changes the resolutions and colors and images being presented to the monitor.

 

From here I just have been drawing out the shortest distance from nitrogens and oxygens to judge the electromagnetic systems that exist in these chemicals.

_____________ >>>>_6______________
____6________ >>>>___6____________
______6______ >>>>_____7___8______
__6___7___8__ >>>>___6___6________
____6___6____ >>>>_6_______6______
________6____ >>>>___________6____
______6___6__ >>>>_____________7__
__6___6___7__ >>>>___________6___6
6___6___6___6 >>>>_________6______
6___6___6____ >>>>_______6________
__6___6______ >>>>_____6__________
__7_-_6______ >>>>___7____________
LSD

_____________ >>>>________6____
__________6__ >>>>__________7__
__6_______7__ >>>>________6___6
6___6___6___6 >>>>______6______
6___6___6____ >>>>____6________
__6___6______ >>>>__6__________
__7_-_6______ >>>>7____________
DMT

_______________________________6__8___
6_______6___8 >>>>__6___________6____
__8_______6__ >>>>____8___________7__
__6_______7__ >>>>______6_______6____
6___6___6____ >>>>________6___6______
6___6___6____ >>>>__________6________
__6___6______ >>>>________6__________
__7_-_6______ >>>>______7____________
Melatonin

__8__________ >>>>____8___________7__
__6_______7__ >>>>______6_______6____
6___6___6____ >>>>________6___6______
6___6___6____ >>>>__________6________
__6___6______ >>>>________6__________
__7_-_6______ >>>>______7____________
Serotonin

Still working on refining this but its just a start, and in order to under stand what this chemical will do...

_________________ >>>>__6______________
________6________ >>>>____6____________
__________6______ >>>>______7___8______
______6___7___8__ >>>>____6___6________
________6___6____ >>>>__6_______6______
____________6____ >>>>____________6____
__________6___6__ >>>>______________7__
__________6___7__ >>>>____________6___6
________6___6___6 >>>>__________6______
________6___6___6 >>>>________6________
__________6___6__ >>>>______7__________
__________7_-_6__
4-DBT

 

So in the natural analysis of the human psyche encompassed in the seratonin receptor's (particularly the 5-HT2a)

There are 3 modes of consciousness I could easily tie to the natural organic mind.

Sleep, Melatonin>

Awake, Serotonin>

Dreaming (Proceeded by Melatonin systems), DMT>

There is a 4th mode Which acts when DMT is proceeded by wakeful serotonin systems.

Tripping, consciousness of the world in which your body does not exists, can be breached via DMT through the serotonin systems, and will channel the dreaming systems directly to the awareness pathways unfiltered and seen as though projected as a dream in which you entirely exist consciously for some time.

when analyzing the three chemicals tied to 3 distinct modes of consciousness you begin to see how these functions lock into and "shift the gears" so to speak.
_________6
__ 6_____7<DMT
_6__6__6__6
_6__6__6_
__ 6__6___
__ 7__6___

the tail nitrogen, 7, shows 6, 6, 7, 6

on serotonin this would be 1, 1, 7, 6 (1= hydrogens)

on melatonin this would be 1, 6, 7, 6

so that would be

DMT = NC2H6 > Dream
S.=NH2 > Wake
M.=NC2H6O > Sleep

 

You are smarter than I hahaha!
I'm going to get back to you after I take organic chem next semester...

 

You need to study up on your pharmacology before you go making arbitrary numbering schemes and assuming that the substituents on a nitrogen will determine the endogenous activity.

2d structural drawings are a horribly poor method of doing structure/activity analysis because it's the shape of the chemical, and where the charge is distributed on it that determines binding and activity more than the actual structure drawn out on paper (although this is more useful for predicting metabolites). An illustration of this is HU-210 and HU-211 - HU 210 is a strong cannabinoid receptor agonist whereas HU-211, a second and totally different drug that only has the stereochemistry of a few bonds reversed, resulting an an almost-identical structure on paper, but with no appreciable activity at cannabinoid receptors - likely due to the vast difference in 3d shape. This is like the difference between someone with two right hands and someone with normal hands - both have 4 fingers and a thumb, a palm etc, but they are obviously not functionally interchangeable!

If you can get yourself a set of molecular models, or even a computer program that allows molecular visualization with overlay, you can see this better. Families of drugs that share affinity at receptors will usually overlay quite well, showing you the 'functional core' of the molecule. DXM, Ketamine, and PCP all overlay to an extent over a shared 'core'. MDPV, Cocaine, and Methylphenidate all have reasonably similar '3d shapes' to each other as well. Color-coding for the elements helps greatly in predicting where charge buildup will occur.

You should also brush up on your IUPAC naming. Nobody in the chemical or pharmacological world is going to know what OxyNitro Base Tryptamine is. Chemical terms have evolved in such a way to reliably describe structures (you can redraw them on paper verbatim from a name) so when you start misusing the terms you can now be talking about any of a myriad of molecules.

Numbering the rings like so:
CONEt2
1
2 3
4

Some quick analysis on your tetracyclic-cored LSD analogs reveals that the 'fourth ring', i.e. the indole's cyclopentyl ring, is horribly strained by the introduction of the third 'piperidine' ring. A relatively flat aromatic binding core is almost always required for activation of 5-HT2a.

One more word of advice, in the interest of harm reduction. Don't ever claim a substance is non toxic unless you have toxicology data in your hand from reliable, verified tests. Metabolites and impurities can cause horrible terrible damage to people when they least expect it if not tested for tox problems (see: MPPP)

No offense, but you seem to be stumbling around in the dark a bit, talking about gold geodesic domes and resonance and other such fuzzy concepts. In the end we are all just chemical reactions. Even the strange and wonderful effects of serotonergics that hit 5-HT2a have been explained - an increase in gain across recurrent circuitry in your brain. Turning the volume up while you have a microphone pointed at a stereo, basically.

See also, http://tripzine.com/pit/signal_theory_poster.pdf

And yes, IAAC (I Am A Chemist).

 

Hey thank you!!! I have lost my account password until now. I'm starting in school for Organic Chemistry and Pharmacology =) I have a website www.geodesicchemistry.com I'm well on my way! I have already found a way to analyze them if you would like to hear it in more detail I will post it soon. I have many synthesis routes soon too

 

Please, don't rely solely on Interwebz sources. Check around, no two synths follow the same protocol. You really need books and notepads that legitimately and correctly line things out; you need to keep copious notes because you will make mistakes, and you'll want to know what not to do wrong next time around. Also, spend the money on decent labware (like borosilicate everything, HDPE plastics, certain kinds of stainless steel, etc.): Coke bottles and turkey basters are a sham for people trying to make organic chemistry "easy". Also, spend PLENTY of time reading up on the hazards of this, that, and the other so you don't create deadly gasses, explosions, or wicked byproducts. This isn't like making a dry ice volcano for third grade chemistry fair. You should also be aware that even with the simplest of teks, none of this stuff is particulary simple. Be cautious, do small batch tests before any procedure of any magnitude, and take your time.