Important article on MDMA

Discussion in 'MDMA - X' started by liquidacrobat, Feb 16, 2011.

  1. liquidacrobat

    liquidacrobat Member

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  2. Skizm

    Skizm Member

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    Thank you Oprah
     
  3. LovesLiquid

    LovesLiquid Member

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  4. guerillabedlam

    guerillabedlam _|=|-|=|_

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    Phil Donahue had a special about MDMA back in the 80's with people claiming therapeutic value, nothing new here except the testimonials.
     
  5. liquidacrobat

    liquidacrobat Member

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    I'm guessing that the content may be similar, but rather than scattered shows, etc., there is a steady flow and increased presence of information on the use of psychedelics and related substances to treat difficult problems like PTSD and terminal anguish. There's a mainstream sense with some of the information - Oprah, NYT, etc. - and there are the clinical trials and research reports. See February press release here ("no cognitive impairment among ecstasy users"): http://www.addictionjournal.org/

    So yes, it feels like progress to me. It feels like a process is happening and it's a good thing to be a part of it (as you clearly are).

    LL: Thank you for the link.
     
  6. guerillabedlam

    guerillabedlam _|=|-|=|_

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    This is all I could find on youtube of it.
    https://www.youtube.com/watch?v=TZnu5FBGOjc"]https://www.youtube.com/watch?v=TZnu5FBGOjc

    HAHA I like the guy who groans!
     
  7. Skizm

    Skizm Member

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    Well, if Oprah is in any way shape or form attached to it and the reports about MDMA are in anyway positive. I think that is quite important. Woman could sell dung if she stuck a book-club sticker on it.
     
  8. guerillabedlam

    guerillabedlam _|=|-|=|_

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    This is all true but while this is happening, we have another drug methylone out that's being demonized by the media which is probably an easier, less side effect free version of MDMA at comparative doses, though maybe not quite as empathogenic.

    I have no issue with the good publicity MDMA is getting but I'm more concerned with the attitude we take towards drugs rather than which celebrity figurehead is putting a good or bad word out. That Donahue special aired in 1985, its taken 25 years to finally pickup the dialog of MDMA's therapeutic value again. Think of how many people could have been helped in that time.

    We repeat history over and over again with drugs. Now that Im at an age where I can logically see it, the propaganda against mephedrone and methylone is the same propaganda against weed in the 30's-40's, against LSD in the 60's, against MDMA in the 80's-90's.

    The funny thing is many of the people buying into the propaganda are in the drug culture.
     
  9. Skizm

    Skizm Member

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    1.00000000001 steps forward 1.000000000001 steps backward.

    Propaganda works!

    I just can't understand the thought process that allows a human being to do it. I understand WHY but not how they rationalize the decision to themselves.

    Thank god for Peter Jennings.
     
  10. liquidacrobat

    liquidacrobat Member

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    Hopefully over time there will continue to be increasing openess to drugs/sacraments/therapeutic tools/so on and so forth. Indeed, wouldn't it be grand if we were all operating from a real awareness of risks and benefits - this many deaths can be attributed to tobacco, this many to alcohol, to marijuana, to MDMA, etc. And then let the safer ones be readily available. And the really dangerous ones like cigarettes be available only with a prescription and accompanied by counseling. (There you go again, in lalaland again. Lalalalogical.)
     
  11. liquidacrobat

    liquidacrobat Member

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    Those crazy fucking Spaniards (bolding added):

    THC Prevents MDMA Neurotoxicity in Mice.
    Touriño C, Zimmer A, Valverde O.

    Departament de Ciències Experimentals i de la Salut, Grup de Recerca en Neurobiologia del Comportament (GRNC), Universitat Pompeu Fabra, Barcelona, Spain. clara.tourino@upf.edu

    Abstract
    The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidant effects. Therefore, THC may have a neuroprotective effect against MDMA-induced neurotoxicity. Mice receiving a neurotoxic regimen of MDMA (20 mg/kg x 4) were pretreated with THC (3 mg/kg x 4) at room (21 degrees C) and at warm (26 degrees C) temperature, and body temperature, striatal glial activation and DA terminal loss were assessed. To find out the mechanisms by which THC may prevent MDMA hyperthermia and neurotoxicity, the same procedure was carried out in animals pretreated with the CB(1) receptor antagonist AM251 and the CB(2) receptor antagonist AM630, as well as in CB(1), CB(2) and CB(1)/CB(2) deficient mice. THC prevented MDMA-induced-hyperthermia and glial activation in animals housed at both room and warm temperature. Surprisingly, MDMA-induced DA terminal loss was only observed in animals housed at warm but not at room temperature, and this neurotoxic effect was reversed by THC administration. However, THC did not prevent MDMA-induced hyperthermia, glial activation, and DA terminal loss in animals treated with the CB(1) receptor antagonist AM251, neither in CB(1) and CB(1)/CB(2) knockout mice. On the other hand, THC prevented MDMA-induced hyperthermia and DA terminal loss, but only partially suppressed glial activation in animals treated with the CB(2) cannabinoid antagonist and in CB(2) knockout animals. Our results indicate that THC protects against MDMA neurotoxicity, and suggest that these neuroprotective actions are primarily mediated by the reduction of hyperthermia through the activation of CB(1) receptor, although CB(2) receptors may also contribute to attenuate neuroinflammation in this process.

    (Pasted from Pubmed)
     
  12. guerillabedlam

    guerillabedlam _|=|-|=|_

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    Youll have to take my word on it, using MDMA and THC consistently together makes you pretty fucking stupid, I can't say I support it.

    Interesting article though for sure.
     
  13. Telepath

    Telepath Banned

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    MDMA sucks. And ruins your body and brain literally.
    Do shrooms or natural drugs.
    And pick them yourself.
     
  14. skyboy877

    skyboy877 Member

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    it helped me in many ways
     

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