Alright, I've been doing some research for quite a few straight hours without much prevail. In the last (no more than) 36 hours, I have been prescribed Celexa (20mg) for anxiety attacks. I'm just wondering if the combination of the two could have any side-effects? Whether they be instant or to be developed over time, I must know. I heard that the increase of seritonin can cause "Seritonin Syndrome", which is too much of it in the brain. As I said, I'm only taking one 20mg pill a day and I do a VERY small amount of cocaine. Like, half a toothpick every few hours. It's been a couple days since I've touched it, since my panic attacks have been kicking in. (My father has anxiety, so I'm guessing the chemical imbalance in the brain is hereditary. He said he first started having these when he was 19, which is about where I stand right about now.) Any information on the combination of the two would be greatly appreciated. Thank you.
I don't know. I don't think mixing SSRI's and serotonin reuptake inhibiting drugs is a good idea. It just seems like a recipe for disaster. SSRI's and antidepressants in general have a range of nasty reactions with other drugs or simply canceling the effect of other drugs out completely. I wouldn't do it. But at the same time I can't give you a definitive answer. I could tell you that using coke with an MAOI would be a possibly deadly combo.
That's a little disappointing, as I only grabed the half-ball a few days before I got prescribed these pills. Thank you for the quick response, I'll continue checking back here to see if any new information has been provided. Edit: LOL. Love the quote in your signature.
If your on SSRI's you have more things to worry about than a coke addiction. Just don't do coke and try to work on your anxiety. Coke wont help with that by the way. if anything its gonna make it way worse. : )
Well considering that doesn't answer my question, those comments are quite useless. That really isn't the problem though. It's hereditary but it was brought on by my current lifestyle. (which I've been forced to break from) (I'm not talking about blow, either) If you actually want to give me a legitimate answer though, feel free to reply. The question was, if you couldn't decode it from my first message, drug-interaction wise, could it have a bad reaction together, even with the amount I'm doing?
Lock the thread. It went okay. 13 hours later, I'm just fuckin' dandy. Still mighty tanked too. Thanks for the... "help".
if all you want is someone telling you something then youre going to walk off thinking along the same lines as you did about 'serotonin syndrome' - ie, partially-informed rubbish. cocaine is a dopaminergic drug. dopaminergic drugs do pretty standard stuff to your body. so do antidepressants! for example, you should have found a lot of info listing common side effects of the medication you take: " fatigue, drowsiness, dry mouth, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, cardiac arrythmia, blood pressure changes" well coke isnt really gonna cause fatigue or drowsiness. all the information you need is readily available. when regarding information about your life and long term health, the last place to look is the drug forum of an internet bulletin board. its a very important place to look, but it should be at the end of your process. so back and find some more specific questions to ask. but to be honest, it looks like the part of you that is going to be knocked around the most is your libido. i doubt youll ever come again.
Pretty specific if you ask me. As for the partially-informed 'rubbish': Clearly I'm only partially-informed, that's just one of the things I heard that can happen, which is why I decided to take my question to people who may have knowledge of the same combinations. I'm sick of the bullshit answers such as "You have better things to worry about". I was looking for more of a scientific perspective. Sure, all the side-effects are listed for each seperate drug (cause that's what I was asking for, right...?) but that stuff was already known and doesn't really help me with -combinations-.
All drugs of abuse, including cocaine, activate the dopamine system in the reward pathway. http://learn.genetics.utah.edu/content/addiction/drugs/ In addition to activating dopamine, cocaine has been shown to affect uptake serotonin:dopamine = 2:3, serotonin:norepinephrine = 2:5 (in rats). http://en.wikipedia.org/wiki/Cocaine#Pharmacology Basically, cocaine causes increased levels of dopamine and norepinephrine mostly, and also increases serotonin. So, as other posts have alluded to, because some serotonin is release and/or blocked from reuptake, a person doing cocaine while on an SSRI does run the risk of developing serotonin syndrome, depending on the dosage of the SSRI and the level of cocaine intake. However, this risk may not be as high as the combination of an SSRI and something such as MDMA (ecstasy), which primarily releases serotonin in addition to dopamine. But the risk is there. Speaking from personal experience, I've been drinking all night, I have been on a half dose of Lexapro for about two weeks, and I've done quite a few solid-sized lines for the past few hours. I must say, the high is not as good as I've had before. But, nothing bad has happened. My heart rate is up, but that's about it. So I think the SSRI reduces the high to some degree. I wouldn't recommend the combo due to various risks, but I don't think it's terribly hazardous either.
serotonin syndrome isnt all that easy to predict, but you don't want it. To me it makes sense that taking 2 different drugs that increase serotonin by different mechanisms would be more dangerous than taking 2 that work through the same mechanism.
I went through a period of heavy amphetamine abuse. Amphetamine is a serotonin releasing agent similar to cocaine being s reuptake inhibitor, I never got serotonin syndrome despite also being on 225 mg Effexor (a high dose) daily. And, yes, I know what serotonin syndrome feels like. I had it once when I mixed my Effexor with doctor prescribed Imitrex, a serotonin agonist headache pill.
