Would acetyl codeine, reacted with Pyridine HCl, be a reasonable way to achieve 6-MAM? Would it be more productive to acetylate codeine, catalytically hydrogenate to 6-acetyl-dihydrocodeine, and then demethylate with HBr, or would that knock off the 6-acetyl group in addition to the 3-methoxy group? And would the aforesaid, using pyridine HCl for demethylation, also break the 6-acetyl group in addition to the 3-methoxy group? If I remember dihydrocodeine can be demethylated with HBr safely without breaking the ether bridge from 4-5. Would oxycodone/morphone be more potent with an acetyl group at the 6 position instead of a double bonded oxygen? Would oxymorphone/codone(9-hydroxymorphone, right?) reacted with thionyl chloride still go from 9-hydroxymophone/codone to 9-hydroxy-6-chloromorphide/codide? Like an oxychloromorphide? Where it's essentially oxymorphone/codone with a chlorine instead of the oxygen at the 6 position? If one had hydromorphone, would acetylating it using acetic anhydride still place a acetyl group at the 6- position, instead of the oxygen double bonded? And finally, does anybody know if 6-acetyl-oxycodeine is toxic, like acetylcodeine is?
