What OPIATES are you ON RIGHT NOW?? Part 5

Discussion in 'Opiates' started by BottleFED, May 26, 2011.

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  1. etkearne

    etkearne Resident Pharmacologist

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    After my successful adventures using Magnesium to beat tolerance, I am now onto chemical number 2 to investigate, and I think, even after the first dose, that it will be promising.

    Agmatine is a neurotransmitter for a rather unheard of receptor that happens to be similar to clonidine, the anti-hypertensive. However, in addition to those effects, it is a very potent NMDA antagonist (Magnesium is a mild Nmda antagonist) which gives it the tolerance beating properties. I took my first dose (a large dose) about an hour before my first 4mg of Suboxone today. I swear, it felt like i took 8mg of Suboxone. I nodded out on only 4mg, which is unheard of. I don't think that's happened since my first week on the stuff.

    I will report more on this chemical as the weeks go on (like Magnesium, I give it a month). It is just a supplement you can buy online, however, most GNC type stores don't know about it as it is rather new and obscure.
     
  2. BottleFED

    BottleFED Member

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    Great write up ETK, thanks for the research, this looks real promising. My only concern is the long terms affects of the substance in question. I was never worried about the MAG because u can find that stuff in everyday vitamins, but this new stuff, any ideas?
    Id give you more POS Reps, but you were that last one i gave some to, LOL.
     
  3. etkearne

    etkearne Resident Pharmacologist

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    Haha. Thanks for the REP. Appreciate it.

    As for the safety of Agmatine- it is actually a endogenous neurotransmitter (ie: produced normally IN the human body), and in all of the clinical journal write-ups I have read, the safety is assumed to be 100% safe. If I find anything to the contrary, I will be sure to report.

    I also want to note the dramatic anti-depressant effect that it manifested. I have been out of my bipolar-depression slump for about a year now, but I still get worked up over various things. The Agmatine supplement seems to provide very balanced, non-euphoric antidepressant/anti-anxiety agent. I almost feel like a 'normal' person.
     
  4. -beatnick

    -beatnick Senior Member

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    blew a roxi 30 2 hours ago still feeling mellow but have to smoke some hash in a bit and then hit upp some shows fo sho.
     
  5. BottleFED

    BottleFED Member

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    picked up my script of Opana, i crushed two about an hour ago, snorted about 3/4 of it, feeling Like i should feel, WooHoo......!
     
  6. etkearne

    etkearne Resident Pharmacologist

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    That must be a nice feeling! You didn't have any Opana for awhile, right? You cycle between that and Oxycodone IR??
     
  7. blitz7341

    blitz7341 Banned

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    just did some monkey water. can you get the magnesium at places like gnc or cvs or is there a special form of it i need to know about? also what is the recommended dose, time to take it etc. im very interested in this. Etkearne if you could PM me with some info i would really apreciate it. thanks bud :)
     
  8. BottleFED

    BottleFED Member

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    Thats right ETK, I do cycle tween the two for no other reason than my scripts are two weeks apart. I have an appt on the 20th to see the Dr and will get them synced up somehow. But I hope we can figure out a way to do it without me having to withdraw to do it...!
     
  9. etkearne

    etkearne Resident Pharmacologist

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    Yeah. It is annoying how doctors script their stuff sometimes. I swear my psychiatrist forgets what he scripted me. I take 4 psych meds all-together, so I am going to the pharmacy 4 random different times throughout the month. And, like your opioid dilemma, I face the same thing with the Ritalin. I have Concerta (Ritalin Extended-Release) that lasts like 3 weeks, then Ritalin Immediate Release for two more weeks. They never land on the same week, so it is a mess!

    Anyways, as for my tolerance-reduction reporting: I have, now, taken only 3.5-4mg of Suboxone (down from 8mg LAST week!) for two straight days now, feeling completely satisfied by that amount. I hope that this keeps up! I will continue to report...
     
  10. BottleFED

    BottleFED Member

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    Yeah its surely a messed up scnario. Im hoping on the 20th that he will just script me some extra, just so I can get to taking these two at same time. While I have only roxy 30s, im doing 2.5 a dose equaling approx 8-10/day, when im on the opana I take one by mouth first thing in the morning for a base and follow it with snorting a half. That last me about 5 hours and then ill snort 1 and then 1 for evening. Im going through 3.5 opana a day. When I have them together, Ill take 1 opana and one roxy. and about every 3-4 hours take another roxy and adding another Opana 8hrs after the first. So when I have them together I take 2 Opana and 5-6 roxys a day, vice 3.5 and 8-10...much better numbers.....
     
  11. oxy420lover

    oxy420lover Member

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    4mg Subutex... Till Thursday then Refill Day!!!!
     
  12. BottleFED

    BottleFED Member

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    Hang in there Oxy bro! Did 100MGs of Opana (2 1/2 40mg ER). Slowing down just a touch.
     
  13. ronny25

    ronny25 Member

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    just ate 25mg oxycodone. I haven't taken any opiates for a month so I should be really happy soon... I have very close to zero tolerance.
     
  14. p0rkch0p

    p0rkch0p Member

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    30mg of roxi, heading to bed, re up on the 20th, lol get this mutha fuckin week over!!!!
     
  15. ness33

    ness33 Member

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    ouch thats pretty close the least amount ive heard you take in a while porkchop
     
  16. p0rkch0p

    p0rkch0p Member

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    yea im poking by on like 40-60 mg a day, i get the shits in the morning but im ok during the day for the most part.......more pain than anything just plain uncomfortable, come on the 20th, i know bottles rooting for it too, lol

    i usually will take 20-30mg for bed so i can sorta sleep no restless legs just sore....then take 20-30 when i get up after i run to the can, lol and 10 maybe 30 in the afternoon, only 30 if i know i got more coming.....or ill space it out and take 15 twice then that will hold me again till my bed time dose.
     
  17. etkearne

    etkearne Resident Pharmacologist

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    I saw my Suboxone doctor today and got my 'refill' (I only bought 15 strips though because I am short on cash ATM). It is pretty much official now that I am no longer a patient for 'opioid dependence' but rather that I am there for off-label treatment for my treatment-resistant depression. That is relieving. I no longer have to take urine tests and be treated like a second-class citizen. The doctor even told me that he is excited to inform other Suboxone doctors at the next convention type thing, that I had such a miraculous improvement on it!

    So, overall it has been a good day. And the Agmatine keeps working wonders. I only took 3mg and feel perfect. I couldn't ask for more (except more money maybe! haha). One thing I noticed about being on opioids for the long-haul is my drastic decrease in greed or materialistic thoughts. I no longer feel like I need to buy pointless objects to keep up with the Jones' and I no longer feel pissed off that I can't really afford to do any of the 'luxury' things that my richer friends can do (fancy restaurants, trips to the Carribean, etc.), because I know that I have something way more valuable: Inner Peace.

    Do any of you (specifically p0rkch0p and BottleFED) feel that way too since you signed up for long-term opioid treatment?
     
  18. BottleFED

    BottleFED Member

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    Will stop by later to pass along my thoughts, just pooped in to see what was posted, later!
     
  19. etkearne

    etkearne Resident Pharmacologist

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    Tolerance (to my amazement) is still lowering with Agmatine supplementation. I actually got nauseous from taking a total of 5mg of Suboxone yesterday. It was one of the strongest opioid highs I ever had. Today I took a total of 3.5mg or so and that dose seems perfect. It is enough to give my day a boost, but not enough to make me sedated or sick. It seems like taking 500mg of the Agmatine (two of the capsules) is sufficient. There are reports to take 1000mg, but I tried that one day and it caused insomnia. Lowering it to 500mg has not caused any noticeable side-effect, other than the tolerance reversal, and also a significant desire to be more sociable and friendy (for some weird reason). However, unlike opioids or stimulants, I can't actually detect any 'change of perception' when I take the Agmatine. It is more like an SSRI type of effect (although it is not related, in the least bit, to SSRIs just to clarify!)

    I hope everyone is doing well and are actively weighing the pros and cons of switching to Suboxone. My main worry about switching to it is that the ceiling dose will be BELOW the dose of Opana/Roxy/MS Contin you are taking now and that you will not get any opioid effect.
     
  20. oxy420lover

    oxy420lover Member

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    100mg MO+ 8mg Dillys!!! Refill Day!!! YaY, I got My Dose Upped!!!! Ms 100mg Twice A Day,Dilly 4mg 4 times a Day!!!!
     
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