Different possible tryptamines

I am curious why there dont seem to be any tryptamines that have anything besides just simple carbon chains on the nitrogen atom. It seems the only options out there are alpha (I thought this means no chain just a hydrogen atom instead but looking at aMT its odd because the methyl group isn't attached to the nitrogen atom, the nitrogen atom just has 2 hydrogen atoms attached to end it, maybe thats not what the a means because i just found a compound called NMT which is the same as DMT but with only one methyl group, and a hydrogen atom in place of the other methyl group. I guess the alpha really means that there is an extra methyl group attached before the nitrogen atom ...not sure though, because if thats what the alpha means then where does the methyl group come in? Maybe the alpha means nothing is on the nitrogen atom and the methyl group is placed before the nitrogen atom), methyl, ethyl, propyl, and isopropyl. Why not any cyclopropyl groups? (maybe this is harder to synthesis)

I understand that butyl groups are less common because it lowers the activity with the chain getting longer, although there is DBT and others. Or what if you made a carbon ring around the nitrogen atom (actually i just found out by reading through thikal that this does exist, its called PYR-T)?

And why isn't there something like DMT but with say 2 bromine (or other halogens) atoms attached to the methyl groups? Or what if you replaced the two methyl groups in DMT with methoxy groups? Maybe it would just be inactive. Or maybe some of these have been made and I've just never heard of them? Any comments?

 

Firstly... good god man, break your thoughts up a bit. One crammed paragraph is hard to read.

Secondly... read this. http://www.erowid.org/archive/rhodium/chemistry/pihkaltour/index.html

Then read Tihkal's compound entries.

Now most of your questions are answered.

They're not psychedelic, most likely.

Alpha is the alpha carbon counting from the nitrogen. It designates which carbon atom he's talking about.

INDOLE-CH2-CH2-NH2

That is tryptamine. The first carbon atom from the amino group is the alpha carbon. The second carbon is the beta carbon. So when you substitute a hydrogen atom on the alpha carbon for a methyl group, you have alpha-methyltryptamine -- AMT.

If you substituted a hydrogen atom on the beta carbon for a methyl group, you'd have beta-methyltryptamine. If you substituted a hydrogen atom at the 1-position of the indole ring (the nitrogen), you'd have 1-methyltryptamine. If you sub a methyl group on the beta carbon and one on the alpha carbon, you have alpha,beta-dimethyltryptamine.

There is one I think but not sure. Read the tihkal entries... it's probably hard to make and expensive.

yes, read tihkal more.

That's an interesting thought. A few reason, I'd assume. #1, it might be hard to make. #2 he doesn't have all the time in the world, and/or #3, just didn't think of it.

Not sure, but I think that would be very unstable. I know hydroxylamines are unstable, and they're theoretically converted into the amine in the body anyway.

 

ok, i'll break it up later dont have time atm. Thank you for your replies, I know I was just kind of rambling bout random stuff but I was very curious about those questions, you answered a lot of it. And I actually did read through a lot of Thikal, I'll check out those other links later. Thanks again

 

I thought about a couple dmt analogs myself (particularly containing bromine and iodine) but I don't really know the basics of chemistry enough to speculate beyond a simple thought. interesting ideas though

 

Become a chemist and experiment. Just don't kill yourself.

 

Yeah, I've thought about this and that would be awesome if I could, but I already have my BS in physics, and I'm super interested in nanotechnology, so I'm probably gonna try to take that path to grad school. If i had enough extra time and money, I would definitely take up your suggestion.

 

^^ that's really cool man. i didn't know you were a fellow scientist

 

well i don't really consider myself a scientist yet, but I do plan on going to grad school at some point. I need to get off my ass and start studying for the GRE!! And i need to try to get some research experience and some referrals for grad school.

 

Good luck on your endeavors, Hallucinations!

 

indeed!

the regular GRE wasn't bad, but the biochem one was hard as fuck!
i had very little to no research experience when i applied to grad schools - guess my grades/interview skills were good enough.

 

Thanks, I'm thinking about stuying psychopharmacology, although that would be a big change in direction, but i am also very interested in that, and it had more guaranteed money behind it.