Prior to this thread full of WIN, You started another thread bowing your chest out proclaiming hey everybody, look at me, I took Tramadol, 500mgs to be exact. Then our good man Orison pointed out that indeed you do appear to have some sort of clue by pointing out that you might have had a seizure had you not taken Kpins. Then of course you pointed out the fact that yeah, thats why I took the Kpins. But of course, you didnt feel like that impressed us enough so you ask this gem of a question: Do You know if i could take 600 mg with 1mg of kpin and avoid a seizure I also dont plan on making taking them a habit, i heard its a nasty withdrawl At this point I guess you wernt happy with not getting a response ot the 600mg question you decided to start another thread. This one asking about seizures from taking 250-300mgs even though you took and survived 500mgs. But sure enough, in keeping with the awesomeness that is the opiate Sub Forum at Hip Forums you got an answer, telling you that yes indeed, you can Wig out on doses of 250-300mgs. But since your Tcount is apparently off the map, you decide to challenge the answer with the Crown jewels of all answers: (insert drumroll) WELL LAST NIGHT I TOOK 250 AND DIDNT HAVE ONE. So there we have it folks, the only answer he was looking for, he had already. According to Bloodwhips logic, having done 500MGs and surviving, you can do 250-300mgs of tramadol and have no problems, be sure to add Kpins like he did though. Seriously, what the fuck is up with the second thread. Just wanted to see your name on the front page in as many places as possible? Why dont you do some research before making yourself look like a fool!
i actually read somewhere that if you are a tolerant seasoned opiate taker, when you run out, taking tramadol will bring on W/D's much faster than taking nothing. ImHO I hate tramadol, it is not a clean true opiate, and doesn't work (for me). JMO=Kserah
weeeee. someone mentioned me .. :sunny: I feel like a star. Then I had to scratch my head and count my fingers. 6pills = 3 sets of fingers and that cumta 300mg .....:2thumbsup: look ma I got thumbs..
I have taken 550mg of Tram before, BUT I had a massive tolerance AND I am scripted 2nd of Klonopin (an anticonvulsant benzo) to take daily. So, simply put, you MIGHT not get a seizure, but it is really playing with fire.
i took 600mgs no seizure........did have tremors while nodding out though edit it was probably more than that cuz i had taken 500mg at once and had 5 more 50mg pills left and woke up with none.........
I've taken over 2000mg of tramadol before with no problems, but all of our bodies react differently to different drugs.
Tramadol is only purported to lower the seizure threshold because it supposedly inhibits GABAa receptors, although from what I understand this is only conjecture. If you are someone who is prone to seizures, an epileptic, then you should be concerned. Otherwise, as long as it is not taken with other psychotropic drugs and in doses that are not absurdly high, the chances of a seizure occuring due to taking Tramadol alone are less then 1%. Taking it with an SSRI is also dangerous as it increases the risk for serotonin syndrome. I've always been curious about this drug because I've taken it numerous times and in fairly high amounts and never got anything out of it other than the mild anti depressive effects. I was discussing this with a friend a few weeks a go and we wondered if perhaps the anti depressant effects on individuals sensitive to such are the cause for all of the hype? I've never even met anyone who has gotten anything even remotely resembling a typical opiod high from it, I've only ever read about it.
Yes it can but depends mostly upon your genetics, family histoy, and next on the amount consumed. It mainly occurs in individuals with undiagnosed or uncontrolled epilepsy. Ultram/Tramadol is a centrally acting mild opioid analgesic (similar to codeine) that binds to mu-opioid receptors as well as inhibits the reuptake of serotonin and norepinephrine (its reuptake inhibition of serotonin and norepinephrine works similar to antidepressants or SSRI's like zoloft, prozac, lexapro, etc.). When taking tramadol Seizures occur in less than 1% of the population (a number that was reached during clinical trials and post-marketing data) and are likely tonic-clonic seizures. These numbers also represent people taking recommended doses (50-100 mg every 4-6 hours; not exceeding 400 mg/day). My personal experience with this drug is extensive. I have studied Medicinal Pharmacology and Neurophysiology for years. I have taken large amounts of this drug and not one time have I had a seizure. The drug itself is somewhat good at killing mild/moderate pain. The euphoria is similar to, but probaly less than codeine. The reuptake of norepinephrine appears to provide one with energy without overtones of anxiety. It lasts longer which is a bonus resulting from a longer half-life of around 5-7 hours. Another plus is its antidepressive/mood stabalizing effects due to its reuptake inhibition of 5-HT and NE as well as its pain killing properties. In my opinion it works a lot better than the current antidepressant/SSRI's out there (i.e. prozac, paxil, lexapro, cymbalta). One negative is that the most effective part of the the drug is its O-desmethyltramadol metabolite (M1) produced by the kidneys, it is 6 times more potent and has a 200 times higher affinity for mu-opioid receptors than tramadol alone. Since M1 is the reason tramadol works at all it needs more time to be metabolized by your body. After oral consumption it takes approximately 1 hour to take effect and reaches peak plama levels around 2-3 hours unlike codeine and its other analogues (hydrocodone, oxycodone) which have an onset of 10-30 minutes and peak in about an 1 hour. If you have a history of epilepsy or seizures stay away. Never take more than is recommended unless directed by your doctor. If you are using it recreationally and taking higher doses then at least have someone with who could help if required. REMEMBER: This drug if taken at higher doses for weeks/months/years will cause Physical and Psychological dependence and withdrawal. Along with opioid like withdrawl symptoms one will also experience SSRI discontinuation withdrawl symptoms. Given its longer half-life (compared to codeine, hydrocodone, and oxycodone) this extremely unpleasent combination of withdrawls could last twice as long. Please be careful.
Yes. The reason for the pro-convulsant effects are an indirect negative allosteric modulation of the GABA receptors. It is most likely due to the combination of the strong NMDA antagonism (which, recall, NMDA antagonists can cause excitation of certain areas of the brain, which means that GABA has a 'harder' time in inhibiting the neural excitation) with the strong Norepinephrine Reuptake Inhibition. NRI's are all known to lower seizure threshold (from antidepressants like Venlafaxine to things like Strattera for ADHD) most likely due to their ability to, again, cause regional brain excitation, which makes GABA inefficient in inhibiting excessive firing rates. So it isn't quite due to direct GABA-A antagonism, but certainly due to the indirect effects on the areas of the brain that are consequently over-excited, making GABA inefficient at inhibiting over-firing. I have also read that it might have something to do with the flux over the voltage-gated Calcium channels (which also regulate overall neuro-excitation), but I haven't read anything definitive about that in any good Neuropsychopharmacology books. But I have seen some papers with abstracts talking about such things.
I've taken 250 maybe 300 at the most and I was alright and I'm not the largest person, but I walked up my tolerance, but not too much. It went from 150 to 250 in a week because I was just bullshitting through em. I don't really think of them of much as an opiate, but more for the SNRI feel. It makes you feel fucking great with a tad bit of odd stimulation.
It does not cause seizures necessarily. I toke once 500 mg with no tolerance, so it depends on the person. A SMALL amount of clonazepam/alprazolam reduces the risk of seizures I heard while alcohol increases it. DOnt overdo benzos on it, you can stop breathing .
Don't take tram after any kind of SSRI or when on it. Prozac got a long half-life, and i got seizure from 375 mg tram after not using prozac for a week, and another time i got seizure from the same 375 mg after not using prozac for 3 weeks. It's really scary for me to take tram now, even when im off SSRI. Seizures were really serious, life-threatening. Also your tolerance doesn't affect seizure probability. Avoid taking lot of tramadol without anyone to help you, and check carefully if you have taken any drugs that low seizure threshold. And i heard that smoking tobacco can increase chance of seizure.
