Hallucinogen efficiency while on SSRIs

I'm looking for the best hallucinogen/psychedelic-type drug that would produce the least or preferably no amount of trip reduction while on an SSRI (citalopram, if specificity is of any relevance).

I am aware that the effects of such recreational 5-HT agonists are evidently rendered inefficacious due to serotonin inhibition. I have tried ~3.5g of shrooms with little to no psychedelic effect. No colors, no visuals, no nothing. How anticlimactic...

So, from research or personal anecdotes (preferably the former, however the latter is equally appreciated), which drug(s) would you recommend?

Thus far, I have considered phenethylamines and DMT, though I have yet to complete my research process on either.

 

It goes like this:

Stop, drop.

 

I'm not quite sure what your post is referring to, but if you're talking about MDMA/ecstasy, then I don't think it would work as the main drug mechanism is especially revolved around the serotonin neuromodulator.

 

What the hell in that post leads you to think that I'm talking about MDMA?

Stop taking your anti-depressant.

Wait a while.

Drop your drug of choice.

If you need anti-depressants up to and during your trip, you should not be tripping.

 

There are anti-depressants known to decrease psychedelic drug effects, and on the vis versa increase the effect. not being on anti-depressants I don't know the risks, but I would look it up. You're quite clearly on the anti-depressant that decreases the effect.But with mixing drugs it isn't always safe so be sure to look it up

 

I would rather not cease ingestion of my prescribed SSRI. I am cognisant to the fact that psychedelics have the ability to either allow me to bask in my spiritual modality (perhaps even experience a true epiphany), or flip my life and very existence into a realm of entropy and utter chaos. Perhaps it will change nothing, and I will open my eyes the next morning and continue as if it were the day before. These are risks I currently believe I am willing to take, and I shall accept whatever fate that will be lain upon my body and soul.

Fuck I'm high

 

I am presently unaware of any SSRIs that are known to intensify a psychedelic trip. Antidepressants include quite a large spectrum of medication, so I suppose what you're referring to is tricyclic antidepressants, which unfortunately does not have the same pharmaco-mechanism as my medication.

and @RooRshack, I thought about MDMA because you said "Stop, drop." and I immediately concluded that my hypothesized equation ended with "roll", as in "Stop, drop, and roll". However, I am most likely just overthinking things, as per usual!

 

i've discontinued my citalopram lately, placebo effects, idk they caused me more worry than they were worth taking, i feel as unstable without them as i do on them, somwhere down the line a was fooled into believing my brain has to biologically perform to a consensualy perceived norm, we're all vibrating at differant frequencies, what the fuck is normal ? normal to him..normal to her..normal to dr whogivafuck from china ?

What a relief it is to realise theres not an established benchmark we're required to conform to when u figure how unique and insecure as each other we all are, what a fool i was to think my anxiety was disturbing the bigger picture haha im just the same as all u other fucking quacks.

Thats what crossed my mind when i thought fuck these pills anyway, but dont listen to me son...i'm mentally unstable :2thumbsup:

 

She's talking about MAOI's, which can potentiate psychedelics quite violently (or do very little) or even cause serious damage or death when combined with a drug with an interaction you have not studied. I could be wrong, I don't THINK SSRI's do anything dangerous when combined with most drugs, other than make you not feel shit.

My point is that you do need some sort of stability and ability to deal with your own mind, before you go facing magnification of it (what psychedelics do).

And you might be totally stable on an SSRI, and able to function, etc. But you're not stable to take psychedelics. And psychedelics might even help you, but to get to that point, you obviously need to be stable enough to stand on your own.

Gotta learn to walk before you can run, or stand before you walk, or whatever......

 

I agree in principle but some people take SSRIs not because they have a frailer mind . . . for example my gf has Tourette's syndrome and SSRIs help her tics. Other than that she has great mental fortitude and actually had to take care of me on one or two trips . When I make doses for us I just give her a little bit more, 10-20% more, and thats only sometimes, with certain compounds. Most others are unaffected really, and she's on benzos too (for same diagnosis).

 

I'm not saying he's weak per se, and you make a good example.

But I still think it's sort of a waste of drugs to have a dulled experience if it's at all possible to stop with the SSRI for at least some time. And assuming it's for depression, I do think OP should face it head on, even if taking an SSRI doesn't denote weakness, he should take it all on. It just might help a lot with whatever the SSRI is for.

As far as saying he'll continue to take his prescribed medication, using that logic he should be asking his doctor about which psychedelic HE recommends.... Oh wait, this is pretty far from following your doctors orders, in the first place...

 

I can tell you that I have experienced strong psychedelia (on 2C-I) multiple times DESPITE taking an extremely high dose of the antidepressant Effexor AND taking a direct 5-HT2A/2C antagonist Zyprexa every day.

I do, however, abstain from the Zyprexa, for two nights prior to tripping. But I don't cut back on the Effexor and things are plenty exciting when it comes time to trip. I do seem to require a bit more than average people (about 25-30 mg oral 2C-I) but that could be due to the source not being pure, so I won't claim that it is due to the Effexor negating it.

 

I think it's up to you (OP) to make the decision. Being depressed on a trip would be the worst thing of your life. But as roorshack is trying to point out, if you can control that (by not being depressed for a couple of days while off the pill), it is an experience worth having. Who knows? you might even be able to get off your anti-depressants for good after an experience.

 

Wow, the MAOI potentiation thing completely flew over my head for a while there! Actually, there are several drugs that can increase the toxicity in SSRIs causing serotonin syndrome (potentially fatal). These drugs include MAOIs, DXM, tricyclic antidepressants, diuretics, alcohol, and more.

Ugh, I despise olanzapine. That shit was a truly horrendous experience... Anyways, yeah, Zyprexa definitely does not have as long as a half-life as SSRIs/SNRIs, etc. As for the Effexor, I would assume that it would attenuate the psychedelic effect quite a bit less as it is both a serotonin and norepinephrine reuptake inhibitor (hence the term SNRI), so typically one would expect only half the serotonin inhibition, if I am correct.

I have been considering the 2C class, however, have you tried any of the more common hallucinogens? It would be interesting to have some insight if you've experienced trips from those. Furthermore, if the substance you consumed was indeed tainted, what drug would you suspect?

Well, I take a larger dose of the SSRI more for anxiety and mood stabilization than for dysthymia (which is currently almost nonexistent). I used to have anxiety even with the meds, but I have very recently lost my virginity to someone I really like to spend time with. I feel as if a good majority of my day-to-day anxieties have dissipated. Not to mention that I'm glowing and shit. :2thumbsup:

 

Would it be painful? yes.

Would he ever be depressed again, or unable to handle it, even given chemical imbalances, again? Very likely no, if he was able to properly utilize the trip.

And yes, depending on the nature of his problems, he very well might be able to ditch meds for good, or might be able to dose (psychedelics, not SSRI) every so often (like with cluster headaches or something) and have the lasting effects hold him over.

 

When i was on an SSRI called lexapro i took a double drop of acid & it was the most intense trip of my life, nothing has ever come close to how insane that trip was!