Any neurotransmitter releasing agent + MAOI

People say that a lot of drugs are dangerous if taken with an MAOI.
Examples are cocaine, speed, MDMA and all drugs that work in similar ways.

The reason for this is that if you inhibit the MAO then the neurotransmitters won't get broken down fast enough and you'll get dangerously high levels of those neurotransmitters.

My question is, if you take a mild MAOI, doesn't that just allow you to get the same effects from drugs with extremely little doses? So for example, a normal MDMA dose is about 100 mg. Maybe if you combine it with an MAOI then suddenly get the same effect from only 5 mg. Wouldn't that be great? That could save you a lot of money, provided that you have a cheap MAOI.
I also think the effect would stay much longer for some drugs, because cocaine for example is broken down by MAO.

So what do you think? I know it's dangerous to combine an MAOI with a normal dose of a drug, but what about combining it with an extremely low dose of a drug? Is it still dangerous then?

 

Someone recently experimented with this on here. They took a small dose of MDMA and maoi, said it extended the duration of the roll but also gave them a bad hangover.

There are various types of MAOI's and with the possible negative interactions with drugs and perhaps unaccounted things like food consumed, it's probably not a wise idea to be messing around with those type of MAOI combos.

 

What kind of hangover? A depression? Or just a huge headache? Because I know the headache can come from eating the wrong foods while you're on an MAOI. It's best to not eat 12 hours before and 12 hours after you use an MAOI.

 

The line between a safe experiment and a botched experiment that embarrassingly lands you in the hospital (try explaining your logic in the ER...) is very thin.

In theory, if you knew the mechanics of your particular body to an infinitely precise degree, you could mix a very very low dose of an MAOI with a Monoamine Releasing Agent or Reuptake Inhibitor. However, since MAOIs are in general, irreversible, you would need a minute fraction of the normal dose if you planned on mixing it with the releasing agent.

You would have to be the cheapest person on earth if you were willing to seriously consider this. Amphetamines are not expensive. Neither is MDMA (more expensive than Amphetamines, but not worth the risk IMO). The only thing I can think of is Cocaine. However, honestly, HOW would you know what dose of the MAOI to take with a certain dose of Cocaine?

You might have a 'guess,' but that is not good enough when it comes to messing around like this. You would have to study your body's reaction to x amount of MAOI with y amount of Cocaine (or whatever), starting from like 1/10 the normal dose of each working up in increments so small it would frustrate even the most patient person. It just plain isn't a good idea.

I am not saying it CAN'T be done without harm, but I am just saying that it is dangerous and if you are that cheap, you need to rethink the drugs you are using and find a cheaper drug of choice!

 

MAOIs tend to also increase/prolong unwanted effects such as headache, nausea, and vasoconstriction, so you're also directly increasing the toxicity of the drug in question. It's just not safe any way you slice it. Yes you could get away with low doses but I don't see the point, you really are playing with fire and would probably cost you more this way in the end.

 

would it be any safer if you took some syran rue seeds for an maoi. Just guessing but it may be safer that a pharm

 

It's never safe for a pharm, don't mess with this.