Cymbalta question

might be better off using "Cymbalta" as a mantra .. Ohm cymbalta ohm.. yeah, serenity now..

 

Sorry... No. Going by the latest usage.

http://bipolar.about.com/od/glossarys/g/gl_snri_ssnri.htm

 

im not a psych but i am a retired MD who has tried every antidepressant invented...
i currently take 20 different meds per day upto 34 pills...ony half are for psych the rest is for HTN and other heart meds...i know my meds

 

An SSRI is a selective serotonin reuptake inhibitor. It selectively targets the Serotonin Transport protein and blocks its ability to uptake excess serotonin in th synapse. An SNRI is a serotonin and norepinephrine reuptake inhibitor. Thus it is not selective so the double S is dropped in most conventions. It works by blocking the SERT transport protein and the NET transport protein which up takes Norepinephrine. Interestingly, NET transports dopamine as well in some parts of the brain which means that elevated dopamine levels are seen in some areas with use of SNRIs like Cymbalta and Effexor.

Cymbalta is different and slightly better than Effexor because it targets NET Transport at the same levels that it targets SERT proteins. Effexor doesn't begin hitting NET at around 200 mg per day which is far above the level at which SERT is occupied at levels of over 90 percent.

 

let's stop this useless fighting and just give the guy some support, fight in another topic not here, anyways hopefully whatver he is using, or will use, will help him long term.