1 day without citalopram

Discussion in 'Pharmaceuticals' started by ChrisFromScotland, Mar 21, 2012.

  1. ChrisFromScotland

    ChrisFromScotland Lang may yer lum reek

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    Yesterday i never took my citalopram (20mg) and today i've actually noticed a differance for the first time, i've never really paid attention to how i feel when i've missed a dose but this time i done it delibrately.

    I feel lyk a high end sports car today, very fast but hard to control. It's quite positive. I was up before 7am, cooked my breakfast, after this post i'm gonna get ready and go out ! usually i'm still in bed at this time though awake but unmotivated.

    Plus it's a sunny day :sunny:
     
  2. etkearne

    etkearne Resident Pharmacologist

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    Yes. If one forgets their SSRI or SNRI, it can induce a temporary pseudo-manic state. However, usually on the second or third day without the medication, discontinuation symptoms start to appear which suck.
     
  3. ChrisFromScotland

    ChrisFromScotland Lang may yer lum reek

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    Yeh i ended up taking my prescribed dose just not long ago, after this mornings outburst that lasted to afternoon i actually started feeling pretty shit :( still don't think their right for me though, citalopram make me feel a little apathetic, doese this resonate with you're experience with SSRI's etkearne ?
     
  4. etkearne

    etkearne Resident Pharmacologist

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    SSRIs induce apathy and anti motivation by their very pharmacological nature. That is why it is best for them to only be used for the severely depressed or anxious folks of whom any improvement would be better than where they currently are.

    For mildly depressed, situationally depressed, or existentially depressed individuals, SSRIS can induce side effects that make their small benefits in mood not worthwhile.

    The reasons mainly lie in that elevating Serotonin in the brain doesn't "make you happy" like the commercials like to pretend. The drugs act by down-regulating or up-regulating the various Serotonin post-synaptic receptors (5-HT receptors). Which direction they go depends on if they are inhibitory or excitiatory. Some receptors which are excitatory are down-regulated and thus things like aggression and obsessive behavior is reduced. However, receptors controlling the release of dopamine can be down-regulated and thus motivation and intense feelings are reduced leading to such side effects.
     
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