Non visual 5ht2a agonist Psychedelics

The 5ht2a serotonin receptor sites are generally regarded as the primary receptor sites for Hallucinogenic activity among Psychedelics. I was thinking about a few Psychedelics that are generally considered non visual or comparatively minimally visual Psychedelics that act on these receptors and I'm seeking info or ideas as to why this may be.

I've assessed MDMA's pharmacology and it's helped provide some insight and its the easiest one for me to wrap my head around as it's a weak agonist at the 5ht2a receptor.

So weak, partial, strong agonist seems fairly straightforward...but the other two compounds sort of throw a wrench in that simplified way of thinking and baffle me more, which are 5-meo-mipt and 5-meo-dmt. (Im sure there are several other compounds that could be discussed but these are what came to mind) The latter is a Strong 5ht2a agonist from what I've read but generally considered devoid of hallucinogenic activity, or considered lacking in Hallucinogenic activity in particular when the frequent comparisons to n,n DMT are made.


So anyone have some info or ideas why some of these compounds may not be as Hallucinogenic as others ?


My brainstorming so far has me thinking that other receptor sites may play a significant role in hallucinogenic activity and that perhaps some of these compounds target different sites of 5ht2a receptors in the brain, perhaps some target the visual cortex receptors more while for example others target receptor areas involved with maybe spatial awareness more.

 

Hi GB,

5-MeO-DMT is certainly not devoid of anything. You mean 5-MeO-MiPT?

 

Hi Transducer! I haven't seen you around in awhile.


I mean both 5-meo-dmt and 5-meo-mipt, Many don't have significant visuals with 5-meo-dmt. Terrence Mckenna describing 5-meo-dmt compared to N,N DMT in the opening minute.

https://www.youtube.com/watch?v=bliTmW_85ww"]https://www.youtube.com/watch?v=bliTmW_85ww

An exercpt of 5-meo-dmt from Tikhal: