I notice alot when I have big meal then pop few hydros lil later doesn't work same as more of empty stomach
i agree with Number48 takeing any c2 or 3 pk after eating is going to make it lesss affetive like i have takeing emm 16 7.5s today i got "higher" off thim erlyer win i didnot eat lunch as to eating dinner tonight.
When I take any sort of drug orally, I try and take it on a completely empty stomach, especially "soma", if you don't take it on an empty stomach it just don't work
it will still work with most things, but the onset will be delayed, and the peak intensity wont be as great, but likely with a bit longer duration.
Having said that, I've also heard that fatty foods can actually potentiate opiates. I've never tried it, so I don't have any first hand experience, but I've heard it before.
It's actually the other way around . Opiates are said to promote intake of preferred foods, or to preferentially increase consumption of fat. I haven't found any mention of fat affecting their potency, though. (Source: medical research papers from PubMed)
What do you mean, that they increase your appetite for fatty foods? I haven't noticed anything like that.