Psychedelic Bump XXXIV

CS, i'd definitely be interested in seeing those papers. might take me awhile to read them, but drop a link here if that's possible or PM me.

interesting stuff, and you explained it quite well.

what kind of program are you doing this research for? (or i guess proposing to do the research - you're probably trying to get money?)
are you still an undergrad?

a few notes that i had written down from a paper or two:

the most "psychedelic" receptors, meaning they were bound by the most number of compounds tested:
5HT2B (hit by TMA, 2ce, 2ct2, psilocin)
5HT1A (hit by DPT, 5-meo-dmt, DOET)
5HT7 (hit by DMT, others?)
5HT1D
...etc.

the least selective psychedelics (hit the most receptors) were:
DMT, DPT, LSD, DOI
liseride?, cis2a?
TMA, 2ce, 2cb,
5meomipt
psilocin

the most selective "psychedelics" this paper tested (could find the reference if i had to) were:
salvinorin A
morphine
MEM
THC
...

typing this all out made me realize that the effects of psychedelics probably has to do with the combination of all the different receptors they hit. so maybe it would make sense for you to start with the more selective compounds?

 

This podcast is from a few years ago, but I thought that some of you might find it interesting. It is an (audio) interview with Hamilton Morris (vice's drug guy).

I found it pretty interesting, at least.

https://longform.org/posts/longform-podcast-60-hamilton-morris

 

I will send you a PM a little bit later today; don't want to post them up here as it would be a little bit too much personal information, but if anyone else is interested I will PM them to you as well!

But thanks, glad to hear I'm not the only one who thinks this is interesting haha. I'm currently working in a Pharmacology lab over the summer, still an undergrad. I managed to get funded for summer research, thus I got my foot in the door, and now I'm on for an Honours Project in my coming final year, so this will be my proposal. I'm not keeping my hopes too high, as I'm an undergrad and it would involve lots of regulatory paper work, but my slight hope is that I could use some gray-zone RC's to at least produce a proof-of-concept.

Thanks for the info on those drugs/receptors as well. You're probably right that I'll have to consider more than the one receptor, but I'm not sure how much I could realistically get done in a year's time. Another interesting aspect (although the GPCR community is still divided on this thought, it seems) is receptor dimers. Hetero- and homo-dimers can cause these drugs to act differently I assume, but that is a whole other can of worms. According to Dr. Nichols, LSD's action may also be mediated by a Dopamine receptor sub-type. And then there are the pharmacokinetic differences. Those selective drugs you've posted mostly hit other receptors (cannabinoid, opioid) so I'm not sure how well they would work. Ideally I'd have a receptor I could test a lot of drugs on to look for functional differences, whereas cannabinoid and opioids would be a few drugs.
Then again, opioid research might be interesting as well, lol.

The one thing I've seen which has me focusing on the 5-HT2A is that a lot of these drugs have the highest affinity for 5-HT2A out of the serotonin receptors they do hit. But the 5-HT2B receptor is another angle I'm interested in that relates to this project - there is some controversy as to if psychedelic drugs can negatively affect heart valves via. the 5-HT2B receptor. My PI has previously studied cardiac stem cells and such, so that might interest him more than the cognitive aspect of hallucinogenic drugs.



On another note, I'm reading a very interesting book called "One River" at the moment. It's about some academics who searched for ethno-botanicals in South America/Mexico. One of the guys, Dr. Schultes, was the one who discovered the identity of "teonanacatl" (Magic Mushrooms in Mexico) and "oliloqui" (Hawaiian Baby Wood Rose in Mexico). Anyway, Gordon Wasson (the guy who "brought mushrooms to America") contacted this Dr. Schultes before he went to Mexico on the hunt for mushrooms. Later, Timothy Leary contacted the same Dr. Schultes before going to try mushrooms himself.

Leary and Schultes corresponded for a little while, but it came to an end when they discussed the recently coined term "psychedelic". Apparently the correct Greek spelling is "psychodelic", but Leary told Schultes that "psychedelic" sounded better and would be more widely accepted. So even before Leary went off the deep end at Harvard, he had been more or less disowned by Schultes for his impromper use of Greek. I thought that was pretty funny.

 

The term and spelling was coined by Humphrey Osmond and later used the same way by Aldous Huxley in Doors of Perception. Brief glance on the etymology looks like they both would work and I agree with leary Psyche-delic sounds much better than Psycho-delic.

 

bump for 2c-b. somehow it pretty much eliminated benzo withdrawal symptoms and I still don't feel bad yet. don't know how long that effect will last but the longer I can go without the better.

I recorded saying LSD, i.e "ell ess dee", then played it in reverse ... WEED CELLAR, or maybe weed seller, i think that's what it said. LOL. (actually it sounds more like EED-SEL-EH or something but i think my brain really just wanted to hear something that sounded like weed seller and "plugged in" a "w" so it would "make sense"). Of course playing this to Siri she says, "I'm not sure what you just said."

She understands LSD just fine (and gives you the wikipedia page for LSD) but "weed cellar" ... she thinks I'm saying "wheat cellar" .. okay close enough Siri, I guess you've never heard of a weed cellar before. She can't understand either though in reverse.

However weed cellar in reverse doesn't sound like LSD, maybe in the vaguest way possible; there's a weird "w" at the end ... but I suppose you can hear anything you want if it's suggestive enough (or you are currently suggestive enough), or sounds "close enough", or under certain "special" conditions and I've only tried weed cellar in reverse under "normal" conditions

Most "regular" reversed speech sentences sound like a foreign language, sort of "Russian" or something and bears just about zero resemblance to any "English" I've ever heard (and probably about the same to any real "Russian" either).

I guess our brains sometimes just really want things to make sense even if they really don't.

 

my annual camping trip is gonna be this weekend. my brother doesn't want to trip this year (he doesn't think it's a good time) and he's bringing a friend that's not into it either. no biggie, but i think i'm still gonna eat 2 or 3 hits myself

this will be the 7th year in a row that i've gone camping at this spot - and the 7th time dosing there too. should be good time, i'm pretty excited.

 

Ah, the annual porkstock camping trip. Have fun! Just went camping myself outside of Boulder and then hiked the 14er Mt. Evans yesterday for my birthday.
Does it mess with you any being the only one tripping when others aren't?

 

Happy Birthday - good way to celebrate.

we'll see haha.

i mean, i've done it before. ideally, they would want to trip with me, but i'm not gonna twist their arm about it.
i've taken a decent dose of acid before on a cruise, where i'm pretty sure no one else was tripping my brother was the only one that knew. i can keep it together on the outside usually no big deal. but that's not to say it's not messing with my head as well.

 

Do you have brown eyes? It bothers me to trip or roll in public cause my pupils are screaming in contrast to my blue eyes. I guess on a cruise you can wear sunglasses though.

 

I have blue eyes but give no fucks. You want to see my saucer eyes fine there is a good reason they look like that.

 

Sounds nice on the camping trips on both your parts - reminds me that I have to get out again. I've only been out once this summer but it was very easy-going camping compared to what I'm used to. Would like to rough it a little bit more than that, haha.

 

Hey all!
Long time, no post. Figured I'd stop in to say hi.
Good to hear you've got some cool ideas and a promising direction for your scientific research CSoul.

As for my bump, I'm planning on trying some pure synthetic mescaline for the second time in the next few weeks. Somehow, I've managed to acquire a pattern of taking mescaline once a summer. It's made its way into my life once a year for at least the past three or four years no. It's funny how psychedelics will do that. The same thing happened to me with mushrooms. Every Good Friday for the past three years, mushrooms would somehow come into my possession, even if I had forgotten about the whole thing. Last year, I was just walking home on Good Friday and I randomly ran into my buddy, who told me that he'd re-spawned our mushroom spores and they'd just harvested, and he gave me a few grams. Anyways, I'm really looking forward to trying some more synthetic mescaline. It is one of the nicest chemicals I've come across in recent years.
​Also, considering stopping by Amsterdam for the first time next week.

I've got the same problem man. My eyes look like dark black holes with a tiny blue rim when I'm tripping.

I've always thought DiPT must have tremendous research potential, but it's something I'd personally shy away from taking as my hearing is already a little messed up and it doesn't sound too recreational. Still, though, a psychedelic with that kind of specificity probably has a lot to teach us about the neurochemistry of hearing.

 

camping trip was a success. my brother decided he DID want to trip...so that was fun

 

I found two "spent tabs", i.e. "completely inert" pieces of paper lol. I've tried microdosing before by cutting a small piece from the corner of a tab, but still got tracers and giggly. I'm not sure what the effects of microdosing are supposed to be exactly, except I was told that it shouldn't produce visuals ??

Anyway, I'll just consider this an experiment to see if there's anything left behind on blotters. I have a good amount more of these spent tabs but can't find them. I have always wondered if taking say 15 of them would be a full trip due to the trace amounts, that is if any trace exists. It is too early to tell at this point as it's only been about 15 mins, i feel a bit giggly but that may just be me. I don't expect anything tbh.



Edit: i forgot to edit the picture first, there was some info on the whiteboard that I didn't notice that I'm not sure I wanted the world to see, so i scratched it out quick. whewww. lol

Edit 2: I don't know if it did anything or not. It's hard to tell.

 

DiPT does sound interesting as far as research goes indeed. There must be something cool going on there. I also have this inkling of a feeling that psychedelics could maybe teach us about the GI system as well. That is where most 5HT receptors are, and think of things like the foamy 2c-e puke that people have reported.

Anyway, sounds lovely on the mescaline, enjoy that!!

Awesome! How many tabs did you guys take?

How were those spent? Did you try to do a liquid dilution earlier or something?

I've never liked microdosing too much - my best success was with 0.5g mushrooms. LSD/NBOMe/2C-B/aMT and others in microdoses have always just made me slightly uncomfortable and less productive. Where are all these silicon valley people who say it makes them creative geniuses, exactly? haha. But I've never given it a strong try, I think it should be on a regularly divided schedule with some decent effort put into focusing on subtle results for a good outcome.

 

I'd like to try DiPT, it supposedly produces some very interesting auditory effects, though I'm not a big fan of extreme auditory effects on psyches, DiPT reportedly has a pretty novel effect on the perception of musical scales and such. Pretty obscure phen i think though.

And they were "spent" because I already took them a few week or a month ago maybe. I always just let them sit on my tongue until it kicks in and then I take them out. I don't think they really did anything, probably not even a trace of anything left (and this was kind of an experiment to see if any lsd was being wasted, I didn't really want to trip today.) I've tried about 1/8th or so from the corner of a tab before which gave me tracers, giddiness, and some pupil dilation, but I think that was still a bit too much to be considered "micro" since I still definitely felt like I was "on acid", and of course I couldn't stick with it and had to do the rest of it . It would be cool though if it was possible to do small doses all the time though. Light doses of LSD are better than weed IMO.

Apparently though what you are supposed to do, or so I've heard is soak the tabs in water (i would guess distilled water without any chlorine which would destroy it) and then just take small sips. I'm still unsure exactly what dose constitutes an LSD microdose, or what types of effects should be noticeable. I have noticed that the more psyches that you've done, the easier it is to "feel" smaller doses, if that makes sense.

 

i've always just eaten the paper, for fear of wasting precious LSD molecules. on this last trip i took while camping, for some reason i could NOT bring myself to swallow all of the paper. i held it in my mouth for over an hour and finally spit it out while standing under a small waterfall. it felt really liberating to finally "let go" of it. i also lost my sunglasses in that same waterfall

i took 2.5 hits and my brother took 1. pretty solid dose for me, and virtually ZERO negative effects. i usually get some stomach issues on the comedown, or some jaw tension, but NONE of that this time. and all on the same doses...

the only blotter that i have used, and then saved was a 25i/25c-nbome tab. i taped it to my list of all my trips...it's still there.

 

I hate acid back pain/ muscle tension. I do feel that the constant laughter contributes to this possibly. I wish small doses of LSD could be used like other people use weed, because to me small LSD doses are the perfect high. I don't think the tolerance though would allow this.

 

what's this about foamy 2c-e puke??

 

I took several tabs that has been weakened due to poor storage once. If you take enough it's still a trip but a dozen was like one or two good hits.